MAPK signalling in cellular metabolism

stress or wellness?

Helmuth Gehart, Susann Kumpf, Arne Ittner, Romeo Ricci*

*Corresponding author for this work

Research output: Contribution to journalReview article

155 Citations (Scopus)

Abstract

Mitogen-activated protein kinase (MAPK) signalling occurs in response to almost any change in the extracellular or intracellular milieu that affects the metabolism of the cell, organ or the entire organism. MAPK-dependent signal transduction is required for physiological metabolic adaptation, but inappropriate MAPK signalling contributes to the development of several interdependent pathological traits, collectively known as metabolic syndrome. Metabolic syndrome leads to life-threatening clinical consequences, such as type 2 diabetes. This Review provides an overview of the MAPK-signalling mechanisms that underly basic cellular metabolism, discussing their link to disease.

Original languageEnglish
Pages (from-to)834-840
Number of pages7
JournalEMBO Reports
Volume11
Issue number11
DOIs
Publication statusPublished - 1 Nov 2010
Externally publishedYes

Keywords

  • diabetes
  • insulin signalling
  • MAPapK
  • metabolism
  • obesity

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