Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

Miriam Vignando; Dominic ffytche; Simon J. G. Lewis; Phil Hyu Lee; Seok Jong Chung; Rimona S. Weil; Michele T. Hu; Clare E. Mackay; Ludovica Griffanti; Delphine Pins; Kathy Dujardin; Renaud Jardri; John-Paul Taylor; Michael Firbank; Grainne McAlonan; Henry K. F. Mak; Shu Leong Ho; Mitul A. Mehta

doi:10.1038/s41467-022-28087-0

Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

Miriam Vignando^*, Dominic ffytche, Simon J. G. Lewis, Phil Hyu Lee, Seok Jong Chung, Rimona S. Weil, Michele T. Hu, Clare E. Mackay, Ludovica Griffanti, Delphine Pins, Kathy Dujardin, Renaud Jardri, John-Paul Taylor, Michael Firbank, Grainne McAlonan, Henry K. F. Mak, Shu Leong Ho, Mitul A. Mehta

^*Corresponding author for this work

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Abstract

Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.

Original language	English
Article number	519
Pages (from-to)	1-16
Number of pages	16
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-28087-0
Publication status	Published - 26 Jan 2022
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

A correction exists for this article. The original has been updated. Correction can be found at doi: 10.1038/s41467-022-28491-6

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Vignando, M., ffytche, D., Lewis, S. J. G., Lee, P. H., Chung, S. J., Weil, R. S., Hu, M. T., Mackay, C. E., Griffanti, L., Pins, D., Dujardin, K., Jardri, R., Taylor, J.-P., Firbank, M., McAlonan, G., Mak, H. K. F., Ho, S. L., & Mehta, M. A. (2022). Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations. Nature Communications, 13(1), 1-16. Article 519. https://doi.org/10.1038/s41467-022-28087-0

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title = "Mapping brain structural differences and neuroreceptor correlates in Parkinson{\textquoteright}s disease visual hallucinations",

abstract = "Parkinson{\textquoteright}s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson{\textquoteright}s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.",

author = "Miriam Vignando and Dominic ffytche and Lewis, {Simon J. G.} and Lee, {Phil Hyu} and Chung, {Seok Jong} and Weil, {Rimona S.} and Hu, {Michele T.} and Mackay, {Clare E.} and Ludovica Griffanti and Delphine Pins and Kathy Dujardin and Renaud Jardri and John-Paul Taylor and Michael Firbank and Grainne McAlonan and Mak, {Henry K. F.} and Ho, {Shu Leong} and Mehta, {Mitul A.}",

note = "Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher. A correction exists for this article. The original has been updated. Correction can be found at doi: 10.1038/s41467-022-28491-6",

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Vignando, M, ffytche, D, Lewis, SJG, Lee, PH, Chung, SJ, Weil, RS, Hu, MT, Mackay, CE, Griffanti, L, Pins, D, Dujardin, K, Jardri, R, Taylor, J-P, Firbank, M, McAlonan, G, Mak, HKF, Ho, SL & Mehta, MA 2022, 'Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations', Nature Communications, vol. 13, no. 1, 519, pp. 1-16. https://doi.org/10.1038/s41467-022-28087-0

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AU - Vignando, Miriam

AU - ffytche, Dominic

AU - Lewis, Simon J. G.

AU - Lee, Phil Hyu

AU - Chung, Seok Jong

AU - Weil, Rimona S.

AU - Hu, Michele T.

AU - Mackay, Clare E.

AU - Griffanti, Ludovica

AU - Pins, Delphine

AU - Dujardin, Kathy

AU - Jardri, Renaud

AU - Taylor, John-Paul

AU - Firbank, Michael

AU - McAlonan, Grainne

AU - Mak, Henry K. F.

AU - Ho, Shu Leong

AU - Mehta, Mitul A.

N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher. A correction exists for this article. The original has been updated. Correction can be found at doi: 10.1038/s41467-022-28491-6

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Y1 - 2022/1/26

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AB - Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.

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Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

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