Mass spectrometry-based N-glycomics of colorectal cancer

Manveen K. Sethi, Susan Fanayan*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    16 Citations (Scopus)
    64 Downloads (Pure)

    Abstract

    Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased molecular understanding of the CRC pathology is warranted to gain insights into the underlying molecular and cellular mechanisms of the disease. Altered protein glycosylation patterns are associated with most diseases including malignant transformation. Recent advances in mass spectrometry and bioinformatics have accelerated glycomics research and present a new paradigm for cancer biomarker discovery. Mass spectrometry (MS)-based glycoproteomics and glycomics, therefore, hold considerable promise to improve the discovery of novel biomarkers with utility in disease diagnosis and therapy. This review focuses on the emerging field of glycomics to present a comprehensive review of advances in technologies and their application in studies aimed at discovering novel glycan-based biomarkers. We will also discuss some of the challenges associated with using glycans as biomarkers.

    Original languageEnglish
    Pages (from-to)29278-29304
    Number of pages27
    JournalInternational Journal of Molecular Sciences
    Volume16
    Issue number12
    DOIs
    Publication statusPublished - Dec 2015

    Bibliographical note

    Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • Cancer
    • Colorectal cancer
    • Glycome
    • Glycosylation
    • N-glycomics

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