Mast cell-restricted tryptases

Structure and function in inflammation and pathogen defense

H. Patrick McNeil*, Roberto Adachi, Richard L. Stevens

*Corresponding author for this work

Research output: Contribution to journalShort survey

75 Citations (Scopus)

Abstract

Mast cells (MCs) are highly specialized immune cells present in mammals and in lower organisms that predate the development of adaptive immunity. The strong evolutionary pressure to retain MCs for >500 million years suggests critical roles for these cells in our survival. In support of this conclusion, no human has been identified to date that lacks MCs, despite the adverse roles of MCs in systemic anaphylaxis and varied inflammatory disorders. MCs express numerous lineage-restricted neutral proteases, and four members of the chromosome 17A3.3 family of tryptases are preferentially expressed in mouse MCs. The anatomical location of MCs at host-environment interfaces has raised the possibility that some of these enzymes are evolutionally conserved because they are needed for combating infectious organisms. Here we review recent insights into the structure and function of MC tryptases in inflammation and host defense against bacteria and other infectious organisms.

Original languageEnglish
Pages (from-to)20785-20789
Number of pages5
JournalJournal of Biological Chemistry
Volume282
Issue number29
DOIs
Publication statusPublished - 20 Jul 2007
Externally publishedYes

Fingerprint Dive into the research topics of 'Mast cell-restricted tryptases: Structure and function in inflammation and pathogen defense'. Together they form a unique fingerprint.

Cite this