Matrix metalloproteinases and their inhibitors in bone remodelling following distraction osteogenesis of the sheep mandible

D. D. Marucci, Y Yu, James McTavish, F Bonar, M. Poole, W Walsh

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review


Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of MMPS (TIMPs) are important in bony remodelling following mandibular lengthening by distraction osteogenesis and can be used to assess bone metabolic activity related to remodelling. By 12 months following distraction levels, of MMP and TIMP activity are comparable to those in undistracted bone, suggesting that bone remodelling is complete. This further supports the assertion that there is no bony relapse following distraction osteogenesis in the sheep mandible, particularly at late time-points and that the regenerate bone at this time is stable.

Original languageEnglish
Title of host publication3rd International Congress on Cranial and Facial Bone Distraction Processes
EditorsE Arnaud, PA Diner
Place of PublicationBologna, Italy
PublisherMonduzzi Editore
Number of pages3
ISBN (Print)8832316145
Publication statusPublished - 2001
Event3rd International Congress of Craniofacial and Maxillofacial Distraction - PARIS, France
Duration: 14 Jun 200116 Jun 2001


Conference3rd International Congress of Craniofacial and Maxillofacial Distraction


  • TIMP-1

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