Maximizing particle concentration in deterministic lateral displacement arrays

Shilun Feng, Alison M. Skelley, Ayad G. Anwer, Guozhen Liu, David W. Inglis*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference abstract

Abstract

We present a deterministic lateral displacement array that allows particles to be concentrated into a central channel, no wider than the surrounding gaps, thereby maximizing the particle enrichment. The performance of the device with hard micro-spheres and cells is investigated. We measure flow patterns and compare them to our analytical model. The 18 µm gap device showed 11-fold enrichment of 7 µm particles and nearly perfect enrichment, of more than 50 fold, for 10 µm particles and Jurkat cells. This work shows a clear path to achieve higher-than-ever particle concentration enhancement in a deterministic microfluidic separation system.

Original languageEnglish
Title of host publicationThe 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1403-1404
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2017
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (21st : 2017) - Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21st

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (21st : 2017)
Abbreviated titleMicroTAS 2017
CountryUnited States
CitySavannah
Period22/10/1726/10/17

Keywords

  • deterministic lateral displacement
  • cell
  • concentration
  • separation

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