Abstract
We present a deterministic lateral displacement array that allows particles to be concentrated into a central channel, no wider than the surrounding gaps, thereby maximizing the particle enrichment. The performance of the device with hard micro-spheres and cells is investigated. We measure flow patterns and compare them to our analytical model. The 18 µm gap device showed 11-fold enrichment of 7 µm particles and nearly perfect enrichment, of more than 50 fold, for 10 µm particles and Jurkat cells. This work shows a clear path to achieve higher-than-ever particle concentration enhancement in a deterministic microfluidic separation system.
Original language | English |
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Title of host publication | The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences |
Publisher | Chemical and Biological Microsystems Society |
Pages | 1403-1404 |
Number of pages | 2 |
ISBN (Electronic) | 9780692941836 |
Publication status | Published - 2017 |
Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017 |
Conference
Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
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Country/Territory | United States |
City | Savannah |
Period | 22/10/17 → 26/10/17 |
Keywords
- deterministic lateral displacement
- cell
- concentration
- separation