Maximizing particle concentration in deterministic lateral displacement arrays

Shilun Feng; Alison M. Skelley; Ayad G. Anwer; Guozhen Liu; David W. Inglis

Maximizing particle concentration in deterministic lateral displacement arrays

Shilun Feng, Alison M. Skelley, Ayad G. Anwer, Guozhen Liu, David W. Inglis^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract

Abstract

We present a deterministic lateral displacement array that allows particles to be concentrated into a central channel, no wider than the surrounding gaps, thereby maximizing the particle enrichment. The performance of the device with hard micro-spheres and cells is investigated. We measure flow patterns and compare them to our analytical model. The 18 µm gap device showed 11-fold enrichment of 7 µm particles and nearly perfect enrichment, of more than 50 fold, for 10 µm particles and Jurkat cells. This work shows a clear path to achieve higher-than-ever particle concentration enhancement in a deterministic microfluidic separation system.

Original language	English
Title of host publication	The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	1403-1404
Number of pages	2
ISBN (Electronic)	9780692941836
Publication status	Published - 2017
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017

Conference

Conference	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/Territory	United States
City	Savannah
Period	22/10/17 → 26/10/17

Keywords

deterministic lateral displacement
cell
concentration
separation

Cite this

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title = "Maximizing particle concentration in deterministic lateral displacement arrays",

abstract = "We present a deterministic lateral displacement array that allows particles to be concentrated into a central channel, no wider than the surrounding gaps, thereby maximizing the particle enrichment. The performance of the device with hard micro-spheres and cells is investigated. We measure flow patterns and compare them to our analytical model. The 18 µm gap device showed 11-fold enrichment of 7 µm particles and nearly perfect enrichment, of more than 50 fold, for 10 µm particles and Jurkat cells. This work shows a clear path to achieve higher-than-ever particle concentration enhancement in a deterministic microfluidic separation system.",

keywords = "deterministic lateral displacement, cell, concentration, separation",

author = "Shilun Feng and Skelley, \{Alison M.\} and Anwer, \{Ayad G.\} and Guozhen Liu and Inglis, \{David W.\}",

year = "2017",

language = "English",

pages = "1403--1404",

booktitle = "The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",

}

Feng, S, Skelley, AM, Anwer, AG, Liu, G & Inglis, DW 2017, Maximizing particle concentration in deterministic lateral displacement arrays. in The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 1403-1404, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, Savannah, United States, 22/10/17.

Maximizing particle concentration in deterministic lateral displacement arrays. / Feng, Shilun; Skelley, Alison M.; Anwer, Ayad G. et al.
The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2017. p. 1403-1404.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract

TY - CHAP

T1 - Maximizing particle concentration in deterministic lateral displacement arrays

AU - Feng, Shilun

AU - Skelley, Alison M.

AU - Anwer, Ayad G.

AU - Liu, Guozhen

AU - Inglis, David W.

PY - 2017

Y1 - 2017

N2 - We present a deterministic lateral displacement array that allows particles to be concentrated into a central channel, no wider than the surrounding gaps, thereby maximizing the particle enrichment. The performance of the device with hard micro-spheres and cells is investigated. We measure flow patterns and compare them to our analytical model. The 18 µm gap device showed 11-fold enrichment of 7 µm particles and nearly perfect enrichment, of more than 50 fold, for 10 µm particles and Jurkat cells. This work shows a clear path to achieve higher-than-ever particle concentration enhancement in a deterministic microfluidic separation system.

AB - We present a deterministic lateral displacement array that allows particles to be concentrated into a central channel, no wider than the surrounding gaps, thereby maximizing the particle enrichment. The performance of the device with hard micro-spheres and cells is investigated. We measure flow patterns and compare them to our analytical model. The 18 µm gap device showed 11-fold enrichment of 7 µm particles and nearly perfect enrichment, of more than 50 fold, for 10 µm particles and Jurkat cells. This work shows a clear path to achieve higher-than-ever particle concentration enhancement in a deterministic microfluidic separation system.

KW - deterministic lateral displacement

KW - cell

KW - concentration

KW - separation

UR - https://www.scopus.com/pages/publications/85079683343

UR - https://cbmsociety.org/conference/proceedings_archive.html

M3 - Conference abstract

AN - SCOPUS:85079683343

SP - 1403

EP - 1404

BT - The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Y2 - 22 October 2017 through 26 October 2017

ER -

Maximizing particle concentration in deterministic lateral displacement arrays

Abstract

Conference

Keywords

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