Measurement duration impacts variability but not impedance measured by the forced oscillation technique in healthy, asthma and COPD subjects

Joanna C. Watts, Claude S. Farah, Leigh M. Seccombe, Blake M. Handley, Robin E. Schoeffel, Amy Bertolin, Jessica Dame Carroll, Gregory G. King, Cindy Thamrin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
14 Downloads (Pure)

Abstract

The forced oscillation technique (FOT) is gaining clinical acceptance, facilitated by more commercial devices and clinical data. However, the effects of variations in testing protocols used in FOT data acquisition are unknown. We describe the effect of duration of data acquisition on FOT results in subjects with asthma, chronic obstructive pulmonary disease (COPD) and healthy controls. FOT data were acquired from 20 healthy, 22 asthmatic and 18 COPD subjects for 60 s in triplicate. The first 16, 30 and 60 s of each measurement were analysed to obtain total, inspiratory and expiratory resistance of respiratory system (Rrs) and respiratory system reactance (Xrs) at 5 and 19 Hz. With increasing duration, there was a decrease in total and expiratory Rrs for healthy controls, total and inspiratory Rrs for asthmatic subjects and magnitude of total and inspiratory Xrs for COPD subjects at 5 Hz. These decreases were small compared to the differences between clinical groups. Measuring for 16, 30 and 60 s provided ⩾3 acceptable breaths in at least 90, 95 and 100% of subjects, respectively. The coefficient of variation for total Rrs and Xrs also decreased with duration. Similar results were found for Rrs and Xrs at 19 Hz. FOT results are statistically, but likely minimally, impacted by acquisition duration in healthy, asthmatic or COPD subjects.

Original languageEnglish
Article number00094-2015
Pages (from-to)1-7
Number of pages7
JournalERJ Open Research
Volume2
Issue number2
DOIs
Publication statusPublished - 6 Jun 2016
Externally publishedYes

Bibliographical note

Copyright ERS 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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