Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI)

Susan Hoe, Daniela Traini, Hak-Kim Chan, Paul M. Young

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

The electrical Next Generation Impactor (eNGI) was assessed against the electrical low-pressure impactor (ELPI) and next generation impactor (NGI) for its capability to characterise particle size and electrostatic charge properties of dry powder inhaler (DPI) formulations. Following assessment, the relationship between inhalational air flow rate and drug powder charge was explored using the eNGI. At a vacuum flow rate of 30 L/min, doses of Pulmicort® (budesonide 400 μg) and Bricanyl® (terbutaline 500 μg) were dispersed into the ELPI, NGI and eNGI, from which particle size profiles and charge profiles were ascertained. Further doses of Pulmicort and Bricanyl were fired into the eNGI at vacuum air flow rates of 45, 60, 75 and 90 L/min, and the resultant size and charge profiles were determined. Particle size profiles at 30 L/min were found to be comparable between the NGI and eNGI, while charge profiles were comparable between the eNGI and ELPI. As air flow rate increased from 30 to 90 L/min, in vitro aerosol performance improved before reaching a peak at 45 L/min (Pulmicort) and 60 L/min (Bricanyl). Net charge also increased with flow rate, the cause of which may be a combination of increased turbulence and aerosol performance. This study demonstrates that the eNGI is capable of electrostatic and particle size characterization of commercial drug-only DPI products.
Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalEuropean Journal of Pharmaceutical Sciences
Volume38
Issue number2
DOIs
Publication statusPublished - 10 Sep 2009
Externally publishedYes

Keywords

  • Electrical Next Generation Impactor (eNGI)
  • Dry powder inhaler
  • Budesonide
  • Terbutaline
  • Triboelectrification

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