Measuring the effects of bronchial thermoplasty using oscillometry

David Langton, Alvin Ing, Joy Sha, Kim Bennetts, Nicole Hersch, McKinny Kwok, Virginia Plummer, Francis Thien, Claude Farah

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background and objective: Bronchial thermoplasty (BT) has been consistently shown to reduce symptoms, exacerbations and the need for reliever medication in patients with severe asthma. Paradoxically, no consistent improvement in spirometry has been demonstrated. It has been suggested that this is due to a reduction in peripheral resistance in small airways, not captured by spirometry. Therefore, in this study, we evaluate the response to BT using oscillometry. Methods: A total of 43 patients with severe asthma from two centres were evaluated at baseline, 6 weeks and 6 months post BT, using spirometry, plethysmography and oscillometry, in addition to medication usage, exacerbation frequency and the Asthma Control Questionnaire (5-item version) (ACQ-5). Results: The mean age was 58.4 ± 11.2 years, forced expiratory volume in 1 s (FEV1) 55.5 ± 20.1% predicted, forced expiratory ratio 53.0 ± 14.5% and FEV1 response to salbutamol was 14.0 ± 14.5%. Following BT, the group responded to treatment with an improvement in ACQ-5 from 2.9 ± 0.9 at baseline to 1.7 ± 1.1 at 6 months (P < 0.005). There was an 81% reduction in exacerbation frequency (P < 0.001) and 50% of patients were weaned completely from maintenance oral corticosteroids. No changes after treatment were observed in spirometry but the residual volume reduced from 147 ± 38% to 139 ± 39% predicted (P < 0.01). Baseline oscillometry demonstrated high levels of resistance at 5 Hz with normal resistance at 20 Hz, indicating resistance in the small airways was elevated, but no changes were observed in any oscillometry parameter after BT treatment. Conclusion: Lung impedance measured with oscillometry did not change following BT despite marked clinical improvements in patients with severe asthma.

LanguageEnglish
Pages431-436
Number of pages6
JournalRespirology
Volume24
Issue number5
Early online date12 Nov 2018
DOIs
Publication statusPublished - 1 May 2019

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Oscillometry
Spirometry
Asthma
Forced Expiratory Volume
Residual Volume
Plethysmography
Albuterol
Electric Impedance
Vascular Resistance
Adrenal Cortex Hormones
Therapeutics
Maintenance
Lung

Keywords

  • asthma
  • bronchial thermoplasty
  • oscillometry
  • small airways

Cite this

Langton, David ; Ing, Alvin ; Sha, Joy ; Bennetts, Kim ; Hersch, Nicole ; Kwok, McKinny ; Plummer, Virginia ; Thien, Francis ; Farah, Claude. / Measuring the effects of bronchial thermoplasty using oscillometry. In: Respirology. 2019 ; Vol. 24, No. 5. pp. 431-436.
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title = "Measuring the effects of bronchial thermoplasty using oscillometry",
abstract = "Background and objective: Bronchial thermoplasty (BT) has been consistently shown to reduce symptoms, exacerbations and the need for reliever medication in patients with severe asthma. Paradoxically, no consistent improvement in spirometry has been demonstrated. It has been suggested that this is due to a reduction in peripheral resistance in small airways, not captured by spirometry. Therefore, in this study, we evaluate the response to BT using oscillometry. Methods: A total of 43 patients with severe asthma from two centres were evaluated at baseline, 6 weeks and 6 months post BT, using spirometry, plethysmography and oscillometry, in addition to medication usage, exacerbation frequency and the Asthma Control Questionnaire (5-item version) (ACQ-5). Results: The mean age was 58.4 ± 11.2 years, forced expiratory volume in 1 s (FEV1) 55.5 ± 20.1{\%} predicted, forced expiratory ratio 53.0 ± 14.5{\%} and FEV1 response to salbutamol was 14.0 ± 14.5{\%}. Following BT, the group responded to treatment with an improvement in ACQ-5 from 2.9 ± 0.9 at baseline to 1.7 ± 1.1 at 6 months (P < 0.005). There was an 81{\%} reduction in exacerbation frequency (P < 0.001) and 50{\%} of patients were weaned completely from maintenance oral corticosteroids. No changes after treatment were observed in spirometry but the residual volume reduced from 147 ± 38{\%} to 139 ± 39{\%} predicted (P < 0.01). Baseline oscillometry demonstrated high levels of resistance at 5 Hz with normal resistance at 20 Hz, indicating resistance in the small airways was elevated, but no changes were observed in any oscillometry parameter after BT treatment. Conclusion: Lung impedance measured with oscillometry did not change following BT despite marked clinical improvements in patients with severe asthma.",
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Langton, D, Ing, A, Sha, J, Bennetts, K, Hersch, N, Kwok, M, Plummer, V, Thien, F & Farah, C 2019, 'Measuring the effects of bronchial thermoplasty using oscillometry', Respirology, vol. 24, no. 5, pp. 431-436. https://doi.org/10.1111/resp.13439

Measuring the effects of bronchial thermoplasty using oscillometry. / Langton, David; Ing, Alvin; Sha, Joy; Bennetts, Kim; Hersch, Nicole; Kwok, McKinny; Plummer, Virginia; Thien, Francis; Farah, Claude.

In: Respirology, Vol. 24, No. 5, 01.05.2019, p. 431-436.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ing, Alvin

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Langton D, Ing A, Sha J, Bennetts K, Hersch N, Kwok M et al. Measuring the effects of bronchial thermoplasty using oscillometry. Respirology. 2019 May 1;24(5):431-436. https://doi.org/10.1111/resp.13439