Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration

James Melrose*, Cindy Shu, Cara Young, Ronald Ho, Margaret M. Smith, Allan A. Young, Susan S. Smith, Ben Gooden, Andrew Dart, Juan Podadera, Richard C. Appleyard, Christopher B. Little

*Corresponding author for this work

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Medicine & Life Sciences