Mechanisms of transsynaptic degeneration in the aging brain

Roshana Vander Wall; Devaraj Basavarajappa; Alexander Klistorner; Stuart Graham; Yuyi You

doi:10.14336/AD.2024.03019

Mechanisms of transsynaptic degeneration in the aging brain

Roshana Vander Wall^*, Devaraj Basavarajappa, Alexander Klistorner, Stuart Graham, Yuyi You

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

60 Downloads (Pure)

Abstract

A prominent feature in many neurodegenerative diseases involves the spread of the pathology from the initial site of damage to anatomically and functionally connected regions of the central nervous system (CNS), referred to as transsynaptic degeneration (TSD). This review covers the possible mechanisms of both retrograde and anterograde TSD in various age-related neurodegenerative diseases, including synaptically and glial mediated changes contributing to TDS and their potential as therapeutic targets. This phenomenon is well documented in clinical and experimental studies spanning various neurodegenerative diseases and their respective models, with a significant emphasis on the visual pathway, to be explored herein.

Original language	English
Pages (from-to)	2149-2167
Number of pages	19
Journal	Aging and Disease
Volume	15
Issue number	5
DOIs	https://doi.org/10.14336/AD.2024.03019
Publication status	Published - 1 Oct 2024

Bibliographical note

Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Aging
Glia
Neurodegenerative Disease
Senescence
Transsynaptic Degeneration

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10.14336/AD.2024.03019Licence: CC BY

Publisher version (open access)Final published version, 1.04 MBLicence: CC BY

Cite this

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title = "Mechanisms of transsynaptic degeneration in the aging brain",

abstract = "A prominent feature in many neurodegenerative diseases involves the spread of the pathology from the initial site of damage to anatomically and functionally connected regions of the central nervous system (CNS), referred to as transsynaptic degeneration (TSD). This review covers the possible mechanisms of both retrograde and anterograde TSD in various age-related neurodegenerative diseases, including synaptically and glial mediated changes contributing to TDS and their potential as therapeutic targets. This phenomenon is well documented in clinical and experimental studies spanning various neurodegenerative diseases and their respective models, with a significant emphasis on the visual pathway, to be explored herein.",

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AU - Wall, Roshana Vander

AU - Basavarajappa, Devaraj

AU - Klistorner, Alexander

AU - Graham, Stuart

AU - You, Yuyi

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N2 - A prominent feature in many neurodegenerative diseases involves the spread of the pathology from the initial site of damage to anatomically and functionally connected regions of the central nervous system (CNS), referred to as transsynaptic degeneration (TSD). This review covers the possible mechanisms of both retrograde and anterograde TSD in various age-related neurodegenerative diseases, including synaptically and glial mediated changes contributing to TDS and their potential as therapeutic targets. This phenomenon is well documented in clinical and experimental studies spanning various neurodegenerative diseases and their respective models, with a significant emphasis on the visual pathway, to be explored herein.

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KW - Neurodegenerative Disease

KW - Senescence

KW - Transsynaptic Degeneration

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JO - Aging and Disease

JF - Aging and Disease

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Mechanisms of transsynaptic degeneration in the aging brain

Abstract

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