Mechanistic investigations of multidentate organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature

Christopher Anstiss*, Jean-Marc Garnier, Fei Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Kinetic experiments were performed on the catalytic cycle of a trifunctional organocatalyst-promoted counterion catalysis of asymmetric aza-Morita-Baylis-Hillman reactions. The catalysis was found to be first order in the trifunctional catalyst with the Michael addition as the rate-limiting step. Temperature variation changed the rate of catalysis but not the enantioselectivity of the reaction.

Original languageEnglish
Pages (from-to)4400-4407
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number19
DOIs
Publication statusPublished - 7 Oct 2010

Bibliographical note

Erratum can be found in Organic and Biomolecular Chemistry, Volume 9(24), 8505, http://dx.doi.org/10.1039/c1ob90070f

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