Medial temporal lobe function during emotional memory in early Alzheimer's disease, mild cognitive impairment and healthy ageing: An fMRI study

Mario A. Parra*, Vivek Pattan, Dichelle Wong, Anna Beaglehole, Jane Lonie, Hong I. Wan, Garry Honey, Jeremy Hall, Heather C. Whalley, Stephen M. Lawrie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
3 Downloads (Pure)

Abstract

Background: Relative to intentional memory encoding, which quickly declines in Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD), incidental memory for emotional stimuli appears to deteriorate more slowly. We hypothesised that tests of incidental emotional memory may inform on different aspects of cognitive decline in MCI and AD.Methods: Patients with MCI, AD and Healthy Controls (HC) were asked to attend to emotional pictures (i.e., positive and neutral) sequentially presented during an fMRI session. Attention was monitored behaviourally. A surprise post-scan recognition test was then administered.Results: The groups remained attentive within the scanner. The post-scan recognition pattern was in the form of (HC = MCI) > AD, with only the former group showing a clear benefit from emotional pictures. fMRI analysis of incidental encoding demonstrated clusters of activation in para-hippocampal regions and in the hippocampus in HC and MCI patients but not in AD patients. The pattern of activation observed in MCI patients tended to be greater than that found in HC.Conclusions: The results suggest that incidental emotional memory might offer a suitable platform to investigate, using behavioural and fMRI measures, subtle changes in the process of developing AD. These changes seem to differ from those found using standard episodic memory tests. The underpinnings of such differences and the potential clinical use of this methodology are discussed in depth.

Original languageEnglish
Article number76
Pages (from-to)1-12
Number of pages12
JournalBMC Psychiatry
Volume13
DOIs
Publication statusPublished - 6 Mar 2013
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Alzheimer's disease
  • Emotional memory
  • fMRI
  • Incidental memory
  • Medial temporal lobe
  • Mild cognitive impairment

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