Mediators on human airway smooth muscle

Carol Armour, Peter Johnson, Sinthia Anticevich, Alaina Ammit, Karen McKay, Margaret Hughes, Judith Black

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

1. Bronchial hyperresponsiveness in asthma may be due to several abnormalities, but must include alterations in the airway smooth muscle responsiveness and/or volume.

2. Increased responsiveness of airway smooth muscle in vitro can be induced by certain inflammatory cell products and by induction of sensitization (atopy).

3. Increased airway smooth muscle growth can also be induced by inflammatory cell products and atopic serum.

4. Mast cell numbers are increased in the airways of asthmatics and, in our studies, in airway smooth muscle that is sensitized and hyperresponsive.

5. We propose that there is a relationship between mast cells and airway smooth muscle cells which, once an allergic process has been initiated, results in the development of critical features in the lungs in asthma.
Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume24
Issue number3-4
DOIs
Publication statusPublished - 1997
Externally publishedYes

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