Medullary orexin in the adrenaline release to hypoglycaemia

Willian S. Korim; Hong Gao; Mazher Mohammed; David G. S. Farmer; Youichirou Ootsuka; Simon McMullan; Robin M. McAllen; Song T. Yao; Andrei V. Derbenev; Anthony J. M. Verberne

Medullary orexin in the adrenaline release to hypoglycaemia

Willian S. Korim, Hong Gao, Mazher Mohammed, David G. S. Farmer, Youichirou Ootsuka, Simon McMullan, Robin M. McAllen, Song T. Yao, Andrei V. Derbenev, Anthony J. M. Verberne

Research output: Contribution to conference › Abstract › peer-review

Abstract

Orexin is a neuropeptide that is involved in feeding, sleeping cycle, and willingness to manifest a behaviour. Previously, we have showed that orexin release in the rostral ventrolateral medulla is essential for the adrenaline release to hypoglycaemia. However, it remained to be understood how this peptide activates the medullary adrenal premotor neurons that drive the release of adrenaline in response to low levels of blood sugar. In this multi-centre collaboration, we validated that orexin neurons facilitate the glutamatergic activation of adrenal premotor sympathetic neurons - responsible for adrenaline-dependent glucose counter regulation in response to hypoglycaemia.

Original language	English
Pages	13
Number of pages	1
Publication status	Published - 15 Nov 2019
Event	Central Cardio-Respiratory Control: Future Directions Conference - Faculty of Medical and Health Sciences University of Auckland, Auckland, New Zealand Duration: 18 Nov 2019 → 19 Nov 2019

Conference

Conference	Central Cardio-Respiratory Control: Future Directions Conference
Abbreviated title	C32019
Country/Territory	New Zealand
City	Auckland
Period	18/11/19 → 19/11/19

Cite this

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title = "Medullary orexin in the adrenaline release to hypoglycaemia",

abstract = "Orexin is a neuropeptide that is involved in feeding, sleeping cycle, and willingness to manifest a behaviour. Previously, we have showed that orexin release in the rostral ventrolateral medulla is essential for the adrenaline release to hypoglycaemia. However, it remained to be understood how this peptide activates the medullary adrenal premotor neurons that drive the release of adrenaline in response to low levels of blood sugar. In this multi-centre collaboration, we validated that orexin neurons facilitate the glutamatergic activation of adrenal premotor sympathetic neurons - responsible for adrenaline-dependent glucose counter regulation in response to hypoglycaemia.",

author = "Korim, {Willian S.} and Hong Gao and Mazher Mohammed and Farmer, {David G. S.} and Youichirou Ootsuka and Simon McMullan and McAllen, {Robin M.} and Yao, {Song T.} and Derbenev, {Andrei V.} and Verberne, {Anthony J. M.}",

year = "2019",

month = nov,

day = "15",

language = "English",

pages = "13",

note = "Central Cardio-Respiratory Control: Future Directions Conference, C32019 ; Conference date: 18-11-2019 Through 19-11-2019",

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T1 - Medullary orexin in the adrenaline release to hypoglycaemia

AU - Korim, Willian S.

AU - Gao, Hong

AU - Mohammed, Mazher

AU - Farmer, David G. S.

AU - Ootsuka, Youichirou

AU - McMullan, Simon

AU - McAllen, Robin M.

AU - Yao, Song T.

AU - Derbenev, Andrei V.

AU - Verberne, Anthony J. M.

PY - 2019/11/15

Y1 - 2019/11/15

N2 - Orexin is a neuropeptide that is involved in feeding, sleeping cycle, and willingness to manifest a behaviour. Previously, we have showed that orexin release in the rostral ventrolateral medulla is essential for the adrenaline release to hypoglycaemia. However, it remained to be understood how this peptide activates the medullary adrenal premotor neurons that drive the release of adrenaline in response to low levels of blood sugar. In this multi-centre collaboration, we validated that orexin neurons facilitate the glutamatergic activation of adrenal premotor sympathetic neurons - responsible for adrenaline-dependent glucose counter regulation in response to hypoglycaemia.

AB - Orexin is a neuropeptide that is involved in feeding, sleeping cycle, and willingness to manifest a behaviour. Previously, we have showed that orexin release in the rostral ventrolateral medulla is essential for the adrenaline release to hypoglycaemia. However, it remained to be understood how this peptide activates the medullary adrenal premotor neurons that drive the release of adrenaline in response to low levels of blood sugar. In this multi-centre collaboration, we validated that orexin neurons facilitate the glutamatergic activation of adrenal premotor sympathetic neurons - responsible for adrenaline-dependent glucose counter regulation in response to hypoglycaemia.

UR - https://www.eventbrite.co.nz/e/central-cardio-respiratory-control-future-directions-conference-tickets-65762135317

M3 - Abstract

SP - 13

T2 - Central Cardio-Respiratory Control: Future Directions Conference

Y2 - 18 November 2019 through 19 November 2019

ER -

Medullary orexin in the adrenaline release to hypoglycaemia

Abstract

Conference

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