Medullary orexin in the adrenaline release to hypoglycaemia

Willian S. Korim, Hong Gao, Mazher Mohammed, David G. S. Farmer, Youichirou Ootsuka, Simon McMullan, Robin M. McAllen, Song T. Yao, Andrei V. Derbenev, Anthony J. M. Verberne

Research output: Contribution to conferenceAbstract


Orexin is a neuropeptide that is involved in feeding, sleeping cycle, and willingness to manifest a behaviour. Previously, we have showed that orexin release in the rostral ventrolateral medulla is essential for the adrenaline release to hypoglycaemia. However, it remained to be understood how this peptide activates the medullary adrenal premotor neurons that drive the release of adrenaline in response to low levels of blood sugar. In this multi-centre collaboration, we validated that orexin neurons facilitate the glutamatergic activation of adrenal premotor sympathetic neurons - responsible for adrenaline-dependent glucose counter regulation in response to hypoglycaemia.
Original languageEnglish
Number of pages1
Publication statusPublished - 15 Nov 2019
EventCentral Cardio-Respiratory Control: Future Directions Conference - Faculty of Medical and Health Sciences University of Auckland, Auckland, New Zealand
Duration: 18 Nov 201919 Nov 2019


ConferenceCentral Cardio-Respiratory Control: Future Directions Conference
Abbreviated titleC32019
CountryNew Zealand

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