Orexin is a neuropeptide that is involved in feeding, sleeping cycle, and willingness to manifest a behaviour. Previously, we have showed that orexin release in the rostral ventrolateral medulla is essential for the adrenaline release to hypoglycaemia. However, it remained to be understood how this peptide activates the medullary adrenal premotor neurons that drive the release of adrenaline in response to low levels of blood sugar. In this multi-centre collaboration, we validated that orexin neurons facilitate the glutamatergic activation of adrenal premotor sympathetic neurons - responsible for adrenaline-dependent glucose counter regulation in response to hypoglycaemia.
|Number of pages||1|
|Publication status||Published - 15 Nov 2019|
|Event||Central Cardio-Respiratory Control: Future Directions Conference - Faculty of Medical and Health Sciences University of Auckland, Auckland, New Zealand|
Duration: 18 Nov 2019 → 19 Nov 2019
|Conference||Central Cardio-Respiratory Control: Future Directions Conference|
|Period||18/11/19 → 19/11/19|
Korim, W. S., Gao, H., Mohammed, M., Farmer, D. G. S., Ootsuka, Y., McMullan, S., ... Verberne, A. J. M. (2019). Medullary orexin in the adrenaline release to hypoglycaemia. 13. Abstract from Central Cardio-Respiratory Control: Future Directions Conference, Auckland, New Zealand.