Melanoma Explorer

a web application to allow easy reanalysis of publicly available and clinically annotated melanoma omics data sets

Dario Strbenac, Kevin Wang, Xinyue Wang, Jiamin Dong, Graham J. Mann, Samuel Mueller, Jean Y. H. Yang*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Validating newly discovered biomarkers in large, publicly available data sets is often difficult and requires specialized computer programming skills. Melanoma Explorer is a web application that enables easy interrogation of melanoma omics data sets that are freely available in online data repositories with a point-and-click interface. Two use cases are demonstrated. First, the relationship of lysozyme mRNA expression is shown to be prognostic in two independent gene expression microarray data sets. Second, a figure from a journal article showing the relationship of tumour thickness and miR-382 abundance is reproduced. Melanoma Explorer is demonstrated to be a useful tool for reproducing results of published studies and providing additional evidence for biomarkers in independent data sets.

Original languageEnglish
Pages (from-to)342-344
Number of pages3
JournalMelanoma Research
Volume29
Issue number3
DOIs
Publication statusPublished - Jun 2019
Externally publishedYes

Keywords

  • bioinformatics
  • biomarkers
  • patient survival

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