Much of the resistance of melanoma to immunotherapy, radiotherapy and cytotoxic treatment is due to an impressive array of molecular defences that derive ultimately from the essential molecular structure of the melanocyte and its biological requirement for defence against apoptosis. The exploration of melanoma susceptibility genes like CDKN2A, CDK4 and MC1R has highlighted a number of key pathways in melanomagenesis. Others have been revealed by a systematic exploration of somatic chromosomal and genetic abnormalities in naevi and melanomas.
|Number of pages||6|
|Publication status||Published - May 2006|