Membrane transport proteins: Implications of sequence comparisons

Jeffrey K. Griffith*, Michael E. Baker, Duncan A. Rouch, Malcolm G P Page, Ronald A. Skurray, Ian T. Paulsen, Keith F. Chater, Stephen A. Baldwin, Peter J F Henderson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

263 Citations (Scopus)


Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

Original languageEnglish
Pages (from-to)684-695
Number of pages12
JournalCurrent Opinion in Cell Biology
Issue number4
Publication statusPublished - 1992
Externally publishedYes


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