Membrane transport proteins

Implications of sequence comparisons

Jeffrey K. Griffith*, Michael E. Baker, Duncan A. Rouch, Malcolm G P Page, Ronald A. Skurray, Ian T. Paulsen, Keith F. Chater, Stephen A. Baldwin, Peter J F Henderson

*Corresponding author for this work

Research output: Contribution to journalArticle

255 Citations (Scopus)


Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

Original languageEnglish
Pages (from-to)684-695
Number of pages12
JournalCurrent Opinion in Cell Biology
Issue number4
Publication statusPublished - 1992
Externally publishedYes

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