Membrane transport proteins: Implications of sequence comparisons

Jeffrey K. Griffith; Michael E. Baker; Duncan A. Rouch; Malcolm G P Page; Ronald A. Skurray; Ian T. Paulsen; Keith F. Chater; Stephen A. Baldwin; Peter J F Henderson

Membrane transport proteins: Implications of sequence comparisons

Jeffrey K. Griffith^*, Michael E. Baker, Duncan A. Rouch, Malcolm G P Page, Ronald A. Skurray, Ian T. Paulsen, Keith F. Chater, Stephen A. Baldwin, Peter J F Henderson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

290 Citations (Scopus)

Abstract

Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

Original language	English
Pages (from-to)	684-695
Number of pages	12
Journal	Current Opinion in Cell Biology
Volume	4
Issue number	4
Publication status	Published - 1992
Externally published	Yes

Cite this

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title = "Membrane transport proteins: Implications of sequence comparisons",

abstract = "Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.",

author = "Griffith, {Jeffrey K.} and Baker, {Michael E.} and Rouch, {Duncan A.} and Page, {Malcolm G P} and Skurray, {Ronald A.} and Paulsen, {Ian T.} and Chater, {Keith F.} and Baldwin, {Stephen A.} and Henderson, {Peter J F}",

year = "1992",

language = "English",

volume = "4",

pages = "684--695",

journal = "Current Opinion in Cell Biology",

issn = "0955-0674",

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T1 - Membrane transport proteins

T2 - Implications of sequence comparisons

AU - Griffith, Jeffrey K.

AU - Baker, Michael E.

AU - Rouch, Duncan A.

AU - Page, Malcolm G P

AU - Skurray, Ronald A.

AU - Paulsen, Ian T.

AU - Chater, Keith F.

AU - Baldwin, Stephen A.

AU - Henderson, Peter J F

PY - 1992

Y1 - 1992

N2 - Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

AB - Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

UR - http://www.scopus.com/inward/record.url?scp=0026660369&partnerID=8YFLogxK

M3 - Article

C2 - 1419050

AN - SCOPUS:0026660369

SN - 0955-0674

VL - 4

SP - 684

EP - 695

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 4

ER -

Membrane transport proteins: Implications of sequence comparisons

Abstract

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