Memory function in a mouse genetic model of Alzheimer's disease

Avdesh Avdesh, Patrick Wong, Ralph N. Martins*, Mathew T. Martin-Iverson

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The E4 allele of the apolipoprotein E (ApoE) gene has been identified as a major risk factor for the development of late onset Alzheimer's disease (AD). However, the mechanisms by which this gene affects AD are not fully understood. Studies of ApoE knock-out (ApoE KO) mice have revealed an exacerbation of two major pathologies that are diagnostic of AD: neurofibrillary tangles and senile plaques. However, evidence as to whether these mice have cognitive deficits is not yet conclusive. This ambiguity may arise partly from confounds associated with reliance on limited memory models, primarily, the Morris water maze task. An 8-arm radial maze task was therefore used to measure spatial memory in the ApoE KO mice, compared to controls over time. Furthermore, the effectiveness of a combination antioxidant therapy (CAT), designed to slow down the progression of AD based on concepts of oxidative stress and inflammatory processes underlying the pathology, was tested on memory ability. A significant strain difference was observed with the ApoE KO mice performing better than controls in terms of reference memory and corrects entries. No significant strain difference was observed for performance in terms of working memory errors. No significant effect of the CAT supplementation was observed.

Original languageEnglish
Pages (from-to)433-444
Number of pages12
JournalJournal of Alzheimer's Disease
Volume25
Issue number3
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • 8-arm radial maze
  • Alzheimer's disease
  • ApoE knock-out mice
  • memory

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