Mesoporous silica particles induce size dependent effects on human dendritic cells

Helen Vallhov*, Susanne Gabrielsson, Maria Strømme, Annika Scheynius, Alfonso E. Garcia-Bennett

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

207 Citations (Scopus)

Abstract

The effects of mesoporous silica nano- (270 nm) and microparticles (2.5 μm) with surface areas above 500 m2/g were evaluated on human monocyte-derived dendritic cells (MDDC). Size- and concentration-dependent effects were seen where the smaller particles and lower concentrations affected MDDC to a minor degree compared to the larger particles and higher concentrations, both in terms of viability, uptake, and immune regulatory markers. Our findings support the further development of mesoporous silica particles in drug and vaccine delivery systems.

Original languageEnglish
Pages (from-to)3576-3582
Number of pages7
JournalNano Letters
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

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