Mesoporous silica particles potentiate antigen-specific T-cell responses

Natalia Kupferschmidt, Khaleda Rahman Qazi, Cecilia Kemi, Helen Vallhov, Alfonso E. Garcia-Bennett, Susanne Gabrielsson, Annika Scheynius*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Aim: To study the adjuvant effect of mesoporous silica particles and their capability of modifying an already existing allergic Th2-like immune response. Materials & methods: The adjuvant effect of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica particles was studied in an antigen-specific ovalbumin (OVA) system in vitro and in vivo. The capacity of the OVA-loaded SBA-15 particles (SBA-15-OVA) to modify an existing immune response was assessed in a murine allergy model. Results: SBA-15-OVA induced significantly stronger OVA-specific splenocyte proliferation compared with OVA alone. Significantly higher IFN-γ production was observed in ex vivo OVA-stimulated splenocytes from SBA-15-OVA-immunized mice compared with mice injected with only SBA-15 or OVA. Treatment of OVA-sensitized mice with SBA-15-OVA modified the immune response with significantly lower serum levels of OVA-specific IgE and higher IgG levels compared with the alum-OVA-treated group. Conclusion: The results are promising for the continued development of mesoporous silica materials for therapeutic applications.

Original languageEnglish
Pages (from-to)1835-1846
Number of pages12
JournalNanomedicine
Volume9
Issue number12
DOIs
Publication statusPublished - 1 Aug 2014
Externally publishedYes

Keywords

  • adjuvant
  • allergy model
  • cytokine
  • mesoporous silica particle
  • ovalbumin
  • splenocyte
  • T cell
  • Ovalbumin
  • Cytokine
  • Splenocyte
  • Allergy model
  • Adjuvant
  • Mesoporous silica particle

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