Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish

Lynn Haines, Christine Neyt, Phillippe Gauter, David G. Keenan, Robert J. Bryson-Richardson, Georgina E. Hollway, Nicolas J. Cole, Peter D. Currie*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


Somites give rise to a number of different embryonic cell types, including the precursors of skeletal muscle populations. The lateral aspect of amniote and fish somites have been shown to give rise specifically to hypaxial muscle, including the appendicular muscle that populates fins and limbs. We have investigated the morphogenetic basis for formation of specific hypaxial muscles within the zebrafish embryo and larvae. Transplantation experiments have revealed a developmentally precocious commitment of cells derived from pectoral fin level somites to forming hypaxial and specifically appendicular muscle. The fate of transplanted somites cannot be over-ridden by local inductive signals, suggesting that somitic tissue may be fixed at an early point in their developmental history to produce appendicular muscle. We further show that this restriction in competence is mirrored at the molecular level, with the exclusive expression of the receptor tyrosine kinase met within somitic regions fated to give rise to appendicular muscle. Loss-of-function experiments reveal that Met and its ligand, hepatocyte growth factor, are required for the correct morphogenesis of the hypaxial muscles in which met is expressed. Furthermore, we demonstrate a requirement for Met signaling in the process of pro-neuromast deposition from the posterior lateral line primordia.

Original languageEnglish
Pages (from-to)4857-4869
Number of pages13
Issue number19
Publication statusPublished - Oct 2004
Externally publishedYes


  • Hypaxial muscle
  • Met
  • Zebrafish


Dive into the research topics of 'Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish'. Together they form a unique fingerprint.

Cite this