Metal–organic frameworks (MOFs) for cancer therapy

Mohammad Reza Saeb, Navid Rabiee*, Masoud Mozafari, Francis Verpoort, Leonid G. Voskressensky, Rafael Luque

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
2 Downloads (Pure)


MOFs exhibit inherent extraordinary features for diverse applications ranging from cataly-sis, storage, and optics to chemosensory and biomedical science and technology. Several procedures including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasound techniques have been used to synthesize MOFs with tailored features. A continued attempt has also been directed towards functionalizing MOFs via “post-synthetic modification” mainly by changing linkers (by altering the type, length, functionality, and charge of the linkers) or node components within the MOF framework. Additionally, efforts are aimed towards manipulating the size and morphology of crystallite domains in the MOFs, which are aimed at enlarging their applications window. Today’s knowledge of artificial intelligence and machine learning has opened new pathways to elaborate multiple nanoporous complex MOFs and nano-MOFs (NMOFs) for advanced theranostic, clinical, imaging, and diagnostic purposes. Successful accumulation of a photosensitizer in cancerous cells was a significant step in cancer therapy. The application of MOFs as advanced materials and systems for cancer therapy is the main scope beyond this perspective. Some challenging aspects and promising features in MOF-based cancer diagnosis and cancer therapy have also been discussed.

Original languageEnglish
Article number7277
Pages (from-to)1-10
Number of pages10
Issue number23
Publication statusPublished - 1 Dec 2021

Bibliographical note

Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • metal-organic frameworks (MOFs)
  • cancer therapy
  • biotechnology
  • nanomedicine


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