Metastasis-specific patterns of response and progression with anti-PD-1 treatment in metastatic melanoma

Jenny H. J. Lee, Megan Lyle, Alexander M. Menzies, Matthew M. K. Chan, Serigne Lo, Arthur Clements, Matteo S. Carlino, Richard F. Kefford, Georgina V. Long*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)


    This study evaluated patterns of response as discerned by comprehensive metastasis-specific analysis in metastatic melanoma patients receiving anti-PD-1 antibodies. Bi-dimensional measurements of every metastasis in patients enrolled in the KEYNOTE-001 trial at a single institution were obtained at baseline and throughout treatment. Twenty-seven evaluable patients had 399 baseline metastases measurable on CT imaging. Complete response (CR) which occurred in 52.6% of metastases was smaller (mean 223 mm2 versus 760 mm2, p <.01) and occurred more frequently in the lungs (65% versus 39.4%, p <.01). Response was heterogenous (new/progressing metastases alongside CR metastases) at first assessment in 4/14 patients with objective response (OR) as opposed to 7/13 patients with non-OR. CR of individual metastases is common and influenced by site and size. Most patients with OR demonstrate homogenous regression in all metastases at the first assessment. In contrast, patients with early heterogeneity had a poor outcome.

    Original languageEnglish
    Pages (from-to)404-410
    Number of pages7
    JournalPigment Cell and Melanoma Research
    Issue number3
    Publication statusPublished - 1 May 2018


    • immune-related response criteria
    • immunotherapy
    • melanoma
    • pembrolizumab
    • programmed-death receptor 1


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