Metastatic small-cell neuroendocrine carcinoma simulating circumscribed choroidal hemangioma

Kate E. Leahy, Tanya Karaconji, Valli Thanni, Anita Achan, Adrian T. Fung

Research output: Contribution to journalArticlepeer-review


Aim: To report a case of metastatic small-cell neuroendocrine carcinoma presenting as an isolated choroidal mass and initially misdiagnosed as a circumscribed choroidal hemangioma. Methods: The clinical history, fundus findings, imaging, cytology and immunohistochemical features are described. Results: An otherwise healthy 66-year-old man was referred for a left nasal scotoma and a diagnosis of circumscribed choroidal hemangioma. Cytology showed cohesive clusters of small-to-intermediate malignant cells. The atypical cells stained positively for chromogranin, thyroid transcription factor-1 and synaptophysin consistent with small-cell neuroendocrine carcinoma. Conclusion: Smallcell neuroendocrine carcinoma metastatic to the choroid is extremely rare; however, it is particularly aggressive and should be included in the differential diagnosis of isolated choroidal lesions, even in otherwise healthy patients.

Original languageEnglish
Pages (from-to)13-15
Number of pages3
JournalOcular Oncology and Pathology
Issue number1
Publication statusPublished - 1 Jan 2016


  • Choroidal hemangioma
  • Choroidal metastasis
  • Immunohistochemistry
  • Metastasis
  • Neuroendocrine carcinoma
  • Small-cell carcinoma
  • Tumor

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