Abstract
Aim: To report a case of metastatic small-cell neuroendocrine carcinoma presenting as an isolated choroidal mass and initially misdiagnosed as a circumscribed choroidal hemangioma. Methods: The clinical history, fundus findings, imaging, cytology and immunohistochemical features are described. Results: An otherwise healthy 66-year-old man was referred for a left nasal scotoma and a diagnosis of circumscribed choroidal hemangioma. Cytology showed cohesive clusters of small-to-intermediate malignant cells. The atypical cells stained positively for chromogranin, thyroid transcription factor-1 and synaptophysin consistent with small-cell neuroendocrine carcinoma. Conclusion: Smallcell neuroendocrine carcinoma metastatic to the choroid is extremely rare; however, it is particularly aggressive and should be included in the differential diagnosis of isolated choroidal lesions, even in otherwise healthy patients.
| Original language | English |
|---|---|
| Pages (from-to) | 13-15 |
| Number of pages | 3 |
| Journal | Ocular Oncology and Pathology |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2016 |
Keywords
- Choroidal hemangioma
- Choroidal metastasis
- Immunohistochemistry
- Metastasis
- Neuroendocrine carcinoma
- Small-cell carcinoma
- Tumor