Method for the measurement of pressure sensitivty of carotid-femoral pulse wave velocity in humans

Research output: Contribution to journalMeeting abstractpeer-review

Abstract

Background: Carotid-femoral pulse wave velocity (cfPWV), a marker of cardiovascular disease, is modified by both blood pressure and changes in arterial wall properties. Current cfPWV measurement does not differentiate between effects of blood pressure and arterial wall properties. Animal studies show that the blood pressure sensitivity of arterial PWV is indicative of blood vessel remodeling. Measurement of this parameter in humans requires a forced change in blood pressure, as can be achieved by Valsalva maneuver. This study investigated a simplified method of measurement of pressure dependency of cfPWV. Methods: Aortic blood pressure was measured using a validated transfer function from a brachial cuff waveform together with cfPWV in 27 subjects (15 female, 36 ± 19 years) in both the standing and supine position. The additional change in hydrostatic pressure across the carotid-femoral path length was estimated using body surface distances. Results: Diastolic blood pressure changed for all subjects (standing 83 ± 8 mmHg, supine 70 ± 8 mmHg, p < 0.001). Hydrostatic change in pressure across the carotid-femoral path added a further difference of 19 ± 2 mmHg (p < 0.001). Standing cfPWV was 7.3 ± 2.2 m/s and supine cfPWV 5.2 ± 1.3 m/s (p < 0.001). The resulting pressure sensitivity of cfPWV ranged from 2.7 to 39.4 cm/s/mmHg and had a correlation with age (0.2 cm/s/year, R2 = 0.35, p < 0.001). Conclusions: Measuring cfPWV and blood pressure in the standing and supine position provides a method of calculation of pressure sensitivity of cfPWV that could be easily implemented in any research laboratory or clinic and may provide predictive information beyond either cfPWV or blood pressure alone.
Original languageEnglish
Article number2.1
Pages (from-to)40-41
Number of pages2
JournalArtery Research
Volume12
Issue numberC
DOIs
Publication statusPublished - 2015
EventAssociation for Research into Arterial Structure and Physiology Conference 2015: ARTERY 2015 - Krakow, Poland
Duration: 13 Oct 201515 Oct 2015

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Fingerprint Dive into the research topics of 'Method for the measurement of pressure sensitivty of carotid-femoral pulse wave velocity in humans'. Together they form a unique fingerprint.

Cite this