Method of producing chemicals in yeast

Thomas Williams (Inventor), Ian Paulsen (Inventor)

Research output: Patent

Abstract

The present invention relates to methods for engineering yeast strains which can be used in the production of industrially important chemicals. Nucleic acids encoding components of the methanol utilization pathway are used to modify yeast cells such as Saccharomyces cerevisiae to enable them to grow in media in which methanol is the only or main energy source. The nucleic acids may encode proteins including alcohol oxidase, dihydroxyacetone synthase, dihydroxyacetone kinase, fructose- 1-6-bisphosphate aldolase, fructose-1-6-bisphosphatase, sedoheptulose bisphosphatase, ribose-5-phosphate isomerase, D-ribulose-5-phosphate-3-epimerase, transketolase 1 or 2, transaldolase and formaldehyde dehydrogenase.

Original languageEnglish
Patent numberWO2018132871
IPCC12N 1/15 2006.01,C12N 1/32 2006.01,C12N 15/81 2006.01,C07C 31/04 2006.01
Priority date17/01/17
Filing date17/01/18
Publication statusSubmitted - 26 Jul 2018

Bibliographical note

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)

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