Methodological advances enabled by the construction of a synthetic yeast genome

Daniel Schindler; Roy S. K. Walker; Yizhi Cai

doi:10.1016/j.crmeth.2024.100761

Methodological advances enabled by the construction of a synthetic yeast genome

Daniel Schindler^*, Roy S. K. Walker, Yizhi Cai^*

^*Corresponding author for this work

School of Natural Sciences

Research output: Contribution to journal › Comment/opinion › peer-review

6 Citations (Scopus)

59 Downloads (Pure)

Abstract

The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17^th de novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.

Original language	English
Article number	100761
Pages (from-to)	1-7
Number of pages	7
Journal	Cell Reports Methods
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/j.crmeth.2024.100761
Publication status	Published - 22 Apr 2024

Bibliographical note

Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1016/j.crmeth.2024.100761

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title = "Methodological advances enabled by the construction of a synthetic yeast genome",

abstract = "The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17th de novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.",

author = "Daniel Schindler and Walker, {Roy S. K.} and Yizhi Cai",

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AU - Walker, Roy S. K.

AU - Cai, Yizhi

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N2 - The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17th de novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.

AB - The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17th de novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.

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JO - Cell Reports Methods

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ER -

Methodological advances enabled by the construction of a synthetic yeast genome

Abstract

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COESB: ARC Centre of Excellence in Synthetic Biology

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Methodological advances enabled by the construction of a synthetic yeast genome

Abstract

Bibliographical note

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COESB: ARC Centre of Excellence in Synthetic Biology

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