Methodological advances enabled by the construction of a synthetic yeast genome

Daniel Schindler*, Roy S. K. Walker, Yizhi Cai*

*Corresponding author for this work

Research output: Contribution to journalComment/opinionpeer-review

6 Downloads (Pure)


The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17th de novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.

Original languageEnglish
Article number100761
Pages (from-to)1-7
Number of pages7
JournalCell Reports Methods
Issue number4
Publication statusPublished - 22 Apr 2024

Bibliographical note

Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


Dive into the research topics of 'Methodological advances enabled by the construction of a synthetic yeast genome'. Together they form a unique fingerprint.
  • COESB: ARC Centre of Excellence in Synthetic Biology

    Paulsen, I., Filipovska, A., Parker, R., Nielsen, L. K., Neilan, B. A., Alexandrov, K., Jackson , C., Wodak, J., Rackham, O., Marcellin, E., Gillings, M., Rogers, W., Lee, L., Packer, N., O'Hara, I. M., Speight, R., Vickers, C. E., Beliaev, A., Scott, C., Lacey, J., Mankad, A., Calvert, J., Thomas, G., Rodriguez-Concepcion, M., Fleishman, S., Koepke, M., Ball, M., Turner, N. J., Borneman, A. R., Holowko, M., Goold, H., Ellis, T., Mitchell, L. A. & Dai, J.


    Project: Research

Cite this