Methods and protocols for prediction of immunogenic epitopes

Joo Chuan Tong, Tin Wee Tan, Shoba Ranganathan*

*Corresponding author for this work

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the identification of T-cell epitopes to specific MHC alleles. This article examines existing computational strategies for the study of peptide/MHC interactions. The most important bioinformatics tools and methods with relevance to the study of peptide/MHC interactions have been reviewed. We have also provided guidelines for predicting antigenic peptides based on the availability of existing experimental data.

Original languageEnglish
Pages (from-to)96-108
Number of pages13
JournalBriefings in Bioinformatics
Volume8
Issue number2
DOIs
Publication statusPublished - Mar 2007

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