Methotrexate-induced optic neuropathy

Chandra Balachandran; Peter J McCluskey; G David Champion; G. Michael Halmagyi

Methotrexate-induced optic neuropathy

Chandra Balachandran, Peter J McCluskey, G David Champion, G. Michael Halmagyi

Research output: Contribution to journal › Article › peer-review

Abstract

A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.

Original language	English
Pages (from-to)	440-1
Number of pages	2
Journal	Clinical and Experimental Ophthalmology
Volume	30
Issue number	6
Publication status	Published - Dec 2002
Externally published	Yes

Keywords

Antirheumatic Agents
Female
Humans
Methotrexate
Middle Aged
Optic Atrophy
Optic Nerve
Scotoma
Visual Acuity
Case Reports
Journal Article

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title = "Methotrexate-induced optic neuropathy",

abstract = "A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.",

keywords = "Antirheumatic Agents, Female, Humans, Methotrexate, Middle Aged, Optic Atrophy, Optic Nerve, Scotoma, Visual Acuity, Case Reports, Journal Article",

author = "Chandra Balachandran and McCluskey, {Peter J} and Champion, {G David} and Halmagyi, {G. Michael}",

year = "2002",

month = dec,

language = "English",

volume = "30",

pages = "440--1",

journal = "Clinical and Experimental Ophthalmology",

issn = "1442-6404",

publisher = "Wiley-Blackwell, Wiley",

number = "6",

}

TY - JOUR

T1 - Methotrexate-induced optic neuropathy

AU - Balachandran, Chandra

AU - McCluskey, Peter J

AU - Champion, G David

AU - Halmagyi, G. Michael

PY - 2002/12

Y1 - 2002/12

N2 - A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.

AB - A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.

KW - Antirheumatic Agents

KW - Female

KW - Humans

KW - Methotrexate

KW - Middle Aged

KW - Optic Atrophy

KW - Optic Nerve

KW - Scotoma

KW - Visual Acuity

KW - Case Reports

KW - Journal Article

M3 - Article

C2 - 12427239

VL - 30

SP - 440

EP - 441

JO - Clinical and Experimental Ophthalmology

JF - Clinical and Experimental Ophthalmology

SN - 1442-6404

IS - 6

ER -