Methotrexate-induced optic neuropathy

Chandra Balachandran, Peter J. McCluskey, G. David Champion, G. Michael Halmagyi

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.

Original languageEnglish
Pages (from-to)440-441
Number of pages2
JournalClinical and Experimental Ophthalmology
Issue number6
Publication statusPublished - Dec 2002
Externally publishedYes


  • methotrexate
  • optic neuropathy
  • rheumatoid arthritis
  • side-effect


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