Microbial biotransformation as a source of chemical diversity in cane toad steroid toxins

R. Andrew Hayes, Andrew M. Piggott, Kristian Dalle, Robert J. Capon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The cane toad is an invasive pest that is rapidly colonising northern Australia. The cane toad parotoid gland secretes cardiotoxic steroids (bufadienolides) that are poisoning native predator species. This study reveals bufadienolide diversity within the secretions of Australian cane toads is different to cane toads from overseas, being far more structurally diverse than previously assumed. It is proposed that this variation is mediated by in situ bacterial biotransformation.

Original languageEnglish
Pages (from-to)1790-1792
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number6
DOIs
Publication statusPublished - 15 Mar 2009
Externally publishedYes

Keywords

  • Biotransformation
  • Bufadienolide
  • Bufo marinus
  • Cane toad
  • Chemical ecology

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