Microbial solute transporters

Liam D. H. Elbourne, Karl A. Hassan, Qinghu Ren, Alexander D. Cameron, Peter J. F. Henderson, Ian T. Paulsen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary/reference bookpeer-review

Abstract

The era of structural biology and genomics has opened new horizons in our understanding of complex biological questions. Three dimensional membrane transporter structures from X-ray crystallography, nuclear magnetic resonance, and increasingly, cryo-electron microscopy, have provided us invaluable information on the mechanisms of transporter function, while comparative genomic approaches for the analysis of membrane transport systems have provided insights into how microbes adapt to their environment. The observation that organisms with similar lifestyles and/or ecological niches display similar transporter profiles despite their phylogenetic and taxonomic differences strongly suggest the influence of the ambient environment on an organism’s complement of membrane transport genes.

Original languageEnglish
Title of host publicationEncyclopedia of Microbiology
EditorsThomas Schmidt
Place of PublicationAmsterdam
PublisherElsevier
Pages157-173
Number of pages17
Edition4th
ISBN (Electronic)9780128117378
ISBN (Print)9780128117361
DOIs
Publication statusPublished - 2019

Keywords

  • Archaea
  • Bioinformatics
  • Eubacterial
  • Genome
  • Membrane transporters
  • Phylogenetic profiling
  • Protein family
  • Solute transport

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