Microbial solute transporters

Liam D. H. Elbourne; Karl A. Hassan; Qinghu Ren; Alexander D. Cameron; Peter J. F. Henderson; Ian T. Paulsen

doi:10.1016/B978-0-12-801238-3.66200-1

Microbial solute transporters

Liam D. H. Elbourne, Karl A. Hassan, Qinghu Ren, Alexander D. Cameron, Peter J. F. Henderson, Ian T. Paulsen^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary/reference book › peer-review

3 Citations (Scopus)

Abstract

The era of structural biology and genomics has opened new horizons in our understanding of complex biological questions. Three dimensional membrane transporter structures from X-ray crystallography, nuclear magnetic resonance, and increasingly, cryo-electron microscopy, have provided us invaluable information on the mechanisms of transporter function, while comparative genomic approaches for the analysis of membrane transport systems have provided insights into how microbes adapt to their environment. The observation that organisms with similar lifestyles and/or ecological niches display similar transporter profiles despite their phylogenetic and taxonomic differences strongly suggest the influence of the ambient environment on an organism’s complement of membrane transport genes.

Original language	English
Title of host publication	Encyclopedia of Microbiology
Editors	Thomas Schmidt
Place of Publication	Amsterdam
Publisher	Elsevier
Pages	157-173
Number of pages	17
Edition	4th
ISBN (Electronic)	9780128117378
ISBN (Print)	9780128117361
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.66200-1
Publication status	Published - 2019

Keywords

Archaea
Bioinformatics
Eubacterial
Genome
Membrane transporters
Phylogenetic profiling
Protein family
Solute transport

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10.1016/B978-0-12-801238-3.66200-1

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title = "Microbial solute transporters",

abstract = "The era of structural biology and genomics has opened new horizons in our understanding of complex biological questions. Three dimensional membrane transporter structures from X-ray crystallography, nuclear magnetic resonance, and increasingly, cryo-electron microscopy, have provided us invaluable information on the mechanisms of transporter function, while comparative genomic approaches for the analysis of membrane transport systems have provided insights into how microbes adapt to their environment. The observation that organisms with similar lifestyles and/or ecological niches display similar transporter profiles despite their phylogenetic and taxonomic differences strongly suggest the influence of the ambient environment on an organism{\textquoteright}s complement of membrane transport genes.",

keywords = "Archaea, Bioinformatics, Eubacterial, Genome, Membrane transporters, Phylogenetic profiling, Protein family, Solute transport",

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AU - Elbourne, Liam D. H.

AU - Hassan, Karl A.

AU - Ren, Qinghu

AU - Cameron, Alexander D.

AU - Henderson, Peter J. F.

AU - Paulsen, Ian T.

PY - 2019

Y1 - 2019

N2 - The era of structural biology and genomics has opened new horizons in our understanding of complex biological questions. Three dimensional membrane transporter structures from X-ray crystallography, nuclear magnetic resonance, and increasingly, cryo-electron microscopy, have provided us invaluable information on the mechanisms of transporter function, while comparative genomic approaches for the analysis of membrane transport systems have provided insights into how microbes adapt to their environment. The observation that organisms with similar lifestyles and/or ecological niches display similar transporter profiles despite their phylogenetic and taxonomic differences strongly suggest the influence of the ambient environment on an organism’s complement of membrane transport genes.

AB - The era of structural biology and genomics has opened new horizons in our understanding of complex biological questions. Three dimensional membrane transporter structures from X-ray crystallography, nuclear magnetic resonance, and increasingly, cryo-electron microscopy, have provided us invaluable information on the mechanisms of transporter function, while comparative genomic approaches for the analysis of membrane transport systems have provided insights into how microbes adapt to their environment. The observation that organisms with similar lifestyles and/or ecological niches display similar transporter profiles despite their phylogenetic and taxonomic differences strongly suggest the influence of the ambient environment on an organism’s complement of membrane transport genes.

KW - Archaea

KW - Bioinformatics

KW - Eubacterial

KW - Genome

KW - Membrane transporters

KW - Phylogenetic profiling

KW - Protein family

KW - Solute transport

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SN - 9780128117361

SP - 157

EP - 173

BT - Encyclopedia of Microbiology

A2 - Schmidt, Thomas

PB - Elsevier

CY - Amsterdam

ER -

Microbial solute transporters

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