Microbiota alterations in Alzheimer’s disease: involvement of the kynurenine pathway and inflammation

Michelle L. Garcez, Kelly R. Jacobs, Gilles J. Guillemin

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease considered the major cause of dementia in the elderly. The main pathophysiological features of the disease are neuronal loss (mainly cholinergic neurons), glutamatergic excitotoxicity, extracellular accumulation of amyloid beta, and intracellular neurofibrillary tangles. However, other pathophysiological features of the disease have emerged including neuroinflammation and dysregulation of the kynurenine pathway (KP). The intestinal microbiota is a large and diverse collection of microorganisms that play a crucial role in regulating host health. Recently, studies have highlighted that changes in intestinal microbiota contribute to brain dysfunction in various neurological diseases including AD. Studies suggest that microbiota compositions are altered in AD patients and animal models and that these changes may increase intestinal permeability and induce inflammation. Considering that microbiota can modulate the kynurenine pathway and in turn neuroinflammation, the gut microbiome may be a valuable target for the development of new disease-modifying therapies. The present review aims to link the interactions between AD, microbiota, and the KP.

LanguageEnglish
Pages424-436
Number of pages13
JournalNeurotoxicity Research
Volume36
Issue number2
Early online date14 May 2019
DOIs
Publication statusPublished - 15 Aug 2019

Fingerprint

Kynurenine
Microbiota
Alzheimer Disease
Inflammation
Neurofibrillary Tangles
Cholinergic Neurons
Amyloid
Neurodegenerative Diseases
Dementia
Permeability
Animal Models
Neurodegenerative diseases
Health
Brain
Microorganisms
Cholinergic Agents
Neurons
Gastrointestinal Microbiome
Animals

Keywords

  • Alzheimer’s disease
  • Inflammation
  • Kynurenine pathway
  • Microbiota
  • Probiotics

Cite this

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abstract = "Alzheimer’s disease (AD) is a neurodegenerative disease considered the major cause of dementia in the elderly. The main pathophysiological features of the disease are neuronal loss (mainly cholinergic neurons), glutamatergic excitotoxicity, extracellular accumulation of amyloid beta, and intracellular neurofibrillary tangles. However, other pathophysiological features of the disease have emerged including neuroinflammation and dysregulation of the kynurenine pathway (KP). The intestinal microbiota is a large and diverse collection of microorganisms that play a crucial role in regulating host health. Recently, studies have highlighted that changes in intestinal microbiota contribute to brain dysfunction in various neurological diseases including AD. Studies suggest that microbiota compositions are altered in AD patients and animal models and that these changes may increase intestinal permeability and induce inflammation. Considering that microbiota can modulate the kynurenine pathway and in turn neuroinflammation, the gut microbiome may be a valuable target for the development of new disease-modifying therapies. The present review aims to link the interactions between AD, microbiota, and the KP.",
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Microbiota alterations in Alzheimer’s disease : involvement of the kynurenine pathway and inflammation. / Garcez, Michelle L.; Jacobs, Kelly R.; Guillemin, Gilles J.

In: Neurotoxicity Research, Vol. 36, No. 2, 15.08.2019, p. 424-436.

Research output: Contribution to journalReview articleResearchpeer-review

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