Microfluidic device in poly(dimethylsiloxane) integrating sheathless electrospray ionization and sample pre-treatment

Peter Lindberg, Sara Thorslund, Andreas Pettersson Dahlin, Sara Bergström, Per Andrén, Fredrik Nikolajeff, Jonas Bergquist

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

In this study, a microfluidic device, fabricated in PDMS. with an integrated sheathless electrospray emitter tip is described. A sample pre-treatment function was also added into the device, allowing neuropeptides in Ringer's salt solution to be desalted prior to mass spectrometry analyzation. The device was fabricated casting two PDMS substrates from a SU-8 master and subsequently irreversibly bonding them together using corona discharge treatment. The device showed excellent durability and the peptide sample could be analyzed without any traces of salts.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1501-1503
Number of pages3
Volume1
ISBN (Print)0974361119, 9780974361116
Publication statusPublished - 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: 9 Oct 200513 Oct 2005

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period9/10/0513/10/05

Keywords

  • Electrospray ionization
  • Mass spectrometry
  • PDMS
  • Sample desalting

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