Microglia, macrophages, perivascular macrophages, and pericytes: A review of function and identification

Gilles J. Guillemin*, Bruce J. Brew

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

400 Citations (Scopus)

Abstract

The phenotypic differentiation of systemic macrophages that have infiltrated the central nervous system, pericytes, perivascular macrophages, and the "real" resident microglial cells is a major immunocytochemical and immunohistochemical concern for all users of cultures of brain cells and brain sections. It is not only important in assessing the purity of cell cultures; it is also of fundamental importance in the assessment of the pathogenetic significance of perivascular inflammatory phenomena within the brain. The lack of a single membranous and/or biochemical marker allowing conclusive identification of these cells is still a major problem in neurobiology. This review briefly discusses the functions of these cells and catalogs a large number of membranous and biochemical markers, which can assist in the identification of these cells.

Original languageEnglish
Pages (from-to)388-397
Number of pages10
JournalJournal of Leukocyte Biology
Volume75
Issue number3
DOIs
Publication statusPublished - Mar 2004
Externally publishedYes

Keywords

  • Brain
  • Differentiation
  • Monocyte cells

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