Microneedle-enabled therapeutics delivery and biosensing in clinical trials

Junying Zhang; Hailiang Li; Lamyaa Albakr; Yiwen Zhang; Aiyu Lu; Wenlin Chen; Tianyu Shao; Luying Zhu; Hua Yuan; Gongjun Yang; Nial J. Wheate; Lifeng Kang; Chungyong Wu

doi:10.1016/j.jconrel.2023.07.023

Microneedle-enabled therapeutics delivery and biosensing in clinical trials

Junying Zhang, Hailiang Li, Lamyaa Albakr, Yiwen Zhang, Aiyu Lu, Wenlin Chen, Tianyu Shao, Luying Zhu, Hua Yuan, Gongjun Yang, Nial J. Wheate, Lifeng Kang^*, Chungyong Wu

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

53 Citations (Scopus)

132 Downloads (Pure)

Abstract

Microneedles (MNs) are micron-sized protrusions attached to a range of devices that are used in therapeutic delivery and diagnosis. Because MNs can be self-applied, are painless, and can carry multiple therapeutic agents, they have received extensive attention, and have been widely investigated, for local and systemic therapy. Many researchers are currently working to extend the use of MNs to clinical applications. In this review, we provide an update and analysis on MN-based clinical trials since their inception in 2007. The MNs in clinical trials are classified into five types based on their appearance and properties, including: hollow MNs, MN patches, radiofrequency MNs, MN rollers, and other MNs. The various aspects of MN trials are summarized, such as MN types, clinical trial time, and trial regions. This review aims to present an overview of MN development and provide insights for future research in this field. To our knowledge, this is the first review focused on MN clinical trials which showcases the latest applications of this advanced technology in medicine.

Original language	English
Pages (from-to)	687-704
Number of pages	18
Journal	Journal of Controlled Release
Volume	360
DOIs	https://doi.org/10.1016/j.jconrel.2023.07.023
Publication status	Published - Aug 2023
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Clinical trial
Diagnosis
Drug delivery
Microneedle
New therapy
Polymer

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10.1016/j.jconrel.2023.07.023

Publisher version (open access)Final published version, 7.67 MBLicence: CC BY

Cite this

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title = "Microneedle-enabled therapeutics delivery and biosensing in clinical trials",

abstract = "Microneedles (MNs) are micron-sized protrusions attached to a range of devices that are used in therapeutic delivery and diagnosis. Because MNs can be self-applied, are painless, and can carry multiple therapeutic agents, they have received extensive attention, and have been widely investigated, for local and systemic therapy. Many researchers are currently working to extend the use of MNs to clinical applications. In this review, we provide an update and analysis on MN-based clinical trials since their inception in 2007. The MNs in clinical trials are classified into five types based on their appearance and properties, including: hollow MNs, MN patches, radiofrequency MNs, MN rollers, and other MNs. The various aspects of MN trials are summarized, such as MN types, clinical trial time, and trial regions. This review aims to present an overview of MN development and provide insights for future research in this field. To our knowledge, this is the first review focused on MN clinical trials which showcases the latest applications of this advanced technology in medicine.",

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author = "Junying Zhang and Hailiang Li and Lamyaa Albakr and Yiwen Zhang and Aiyu Lu and Wenlin Chen and Tianyu Shao and Luying Zhu and Hua Yuan and Gongjun Yang and Wheate, {Nial J.} and Lifeng Kang and Chungyong Wu",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

month = aug,

doi = "10.1016/j.jconrel.2023.07.023",

language = "English",

volume = "360",

pages = "687--704",

journal = "Journal of Controlled Release",

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T1 - Microneedle-enabled therapeutics delivery and biosensing in clinical trials

AU - Zhang, Junying

AU - Li, Hailiang

AU - Albakr, Lamyaa

AU - Zhang, Yiwen

AU - Lu, Aiyu

AU - Chen, Wenlin

AU - Shao, Tianyu

AU - Zhu, Luying

AU - Yuan, Hua

AU - Yang, Gongjun

AU - Wheate, Nial J.

AU - Kang, Lifeng

AU - Wu, Chungyong

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/8

Y1 - 2023/8

N2 - Microneedles (MNs) are micron-sized protrusions attached to a range of devices that are used in therapeutic delivery and diagnosis. Because MNs can be self-applied, are painless, and can carry multiple therapeutic agents, they have received extensive attention, and have been widely investigated, for local and systemic therapy. Many researchers are currently working to extend the use of MNs to clinical applications. In this review, we provide an update and analysis on MN-based clinical trials since their inception in 2007. The MNs in clinical trials are classified into five types based on their appearance and properties, including: hollow MNs, MN patches, radiofrequency MNs, MN rollers, and other MNs. The various aspects of MN trials are summarized, such as MN types, clinical trial time, and trial regions. This review aims to present an overview of MN development and provide insights for future research in this field. To our knowledge, this is the first review focused on MN clinical trials which showcases the latest applications of this advanced technology in medicine.

AB - Microneedles (MNs) are micron-sized protrusions attached to a range of devices that are used in therapeutic delivery and diagnosis. Because MNs can be self-applied, are painless, and can carry multiple therapeutic agents, they have received extensive attention, and have been widely investigated, for local and systemic therapy. Many researchers are currently working to extend the use of MNs to clinical applications. In this review, we provide an update and analysis on MN-based clinical trials since their inception in 2007. The MNs in clinical trials are classified into five types based on their appearance and properties, including: hollow MNs, MN patches, radiofrequency MNs, MN rollers, and other MNs. The various aspects of MN trials are summarized, such as MN types, clinical trial time, and trial regions. This review aims to present an overview of MN development and provide insights for future research in this field. To our knowledge, this is the first review focused on MN clinical trials which showcases the latest applications of this advanced technology in medicine.

KW - Clinical trial

KW - Diagnosis

KW - Drug delivery

KW - Microneedle

KW - New therapy

KW - Polymer

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DO - 10.1016/j.jconrel.2023.07.023

M3 - Review article

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AN - SCOPUS:85165173052

SN - 0168-3659

VL - 360

SP - 687

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Microneedle-enabled therapeutics delivery and biosensing in clinical trials

Abstract

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Keywords

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