MicroRNA control of interferons and interferon induced anti-viral activity

Lisa M. Sedger*

*Corresponding author for this work

    Research output: Contribution to journalReview article

    33 Citations (Scopus)

    Abstract

    Interferons (IFNs) are cytokines that are spontaneously produced in response to virus infection. They act by binding to IFN-receptors (IFN-R), which trigger JAK/STAT cell signalling and the subsequent induction of hundreds of IFN-inducible genes, including both protein-coding and microRNA genes. IFN-induced genes then act synergistically to prevent virus replication and create an anti-viral state. miRNA are therefore integral to the innate response to virus infection and are important components of IFN-mediated biology. On the other hand viruses also encode miRNAs that in some cases interfere directly with the IFN response to infection. This review summarizes the important roles of miRNAs in virus infection acting both as IFN-stimulated anti-viral molecules and as critical regulators of IFNs and IFN-stimulated genes. It also highlights how recent knowledge in RNA editing influence miRNA control of virus infection.

    Original languageEnglish
    Pages (from-to)781-793
    Number of pages13
    JournalMolecular Immunology
    Volume56
    Issue number4
    DOIs
    Publication statusPublished - 1 Dec 2013

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