Migraine aura: pathophysiology, mimics, and treatment options

Clare L. Fraser*, Jenny L. Hepschke, Bronwyn Jenkins, Sashank Prasad

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Recent insights into the clinical presentation and pathophysiology of migraine aura have paved the way for new treatments for this common but frequently debilitating condition. Marked efflux of cellular potassium and glutamate contributes to the cortical spreading depression that forms the electrophysiological basis of migraine aura phenomena. Secondary vascular perturbations also contribute to the various symptoms of a migraine attack. Calcitonin gene-related peptide (CGRP) plays a key role in many of these steps, and a growing class of CGRP-antagonists have emerged as a novel, efficacious preventative therapy. It is still not fully understood why a preponderance of migraine aura symptoms is visual, and this issue is an active area of research. In addition, the pathophysiological changes responsible for visual snow syndrome are under investigation. Before diagnosing a patient with migraine aura, it is important to consider the differential diagnosis of transient visual phenomena, with attention to clinical features that may suggest conditions such as retinal disorders, transient ischemic attack, or occipital epilepsy.

Original languageEnglish
Pages (from-to)739-748
Number of pages10
JournalSeminars in Neurology
Volume39
Issue number6
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Keywords

  • Aura
  • Migraine
  • Visual snow

Fingerprint

Dive into the research topics of 'Migraine aura: pathophysiology, mimics, and treatment options'. Together they form a unique fingerprint.

Cite this