Mild neuritic changes are increased in the brains of fatally injured older motor vehicle drivers

C. A. Gorrie*, M. Rodriguez, P. Sachdev, J. Duflou, P. M E Waite

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Given the expected increase in the older population and driving in this age group, concerns have been raised about the safety of older drivers. People over 65 years are over-represented in motor vehicle fatalities when calculated by distance driven. They are also at risk of neurodegenerative diseases, such as Alzheimer's disease, that affect cognitive function. We have examined the brains of older drivers (15M:12F) who died as a result of a motor vehicle accident (MVA) to determine the extent of Alzheimer's disease-related neurofibrillary changes (neuritic plaques and neurofibrillary tangles), Lewy body pathology and cerebrovascular disease and compared them to a control group of older licenced drivers (23M:5F) who died of other causes. The prevalence of moderate or severe neuritic plaque pathology was less than expected for the general population of this age and there was no difference between the groups. However, mild neuritic plaque pathology was increased for MVA deaths compared to controls. There was no evidence of vascular dementia or dementia with Lewy bodies. The current mandatory age-related re-licencing procedures in NSW may contribute to the low percentage of drivers with severe pathology. Further research into the role of mild pathology in cognitive impairment and older drivers is warranted.

Original languageEnglish
Pages (from-to)1114-1120
Number of pages7
JournalAccident Analysis and Prevention
Issue number6
Publication statusPublished - Nov 2007
Externally publishedYes


  • Alzheimer's disease
  • Mild cognitive impairment
  • Neuritic plaques
  • Neurofibrillary tangles
  • Older driver


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