Mindfulness-based cognitive therapy in obsessive-compulsive disorder

protocol of a randomized controlled trial

Katrin K. Külz*, Sarah Landmann, Barbara Cludius, Birgit Hottenrott, Nina Rose, Thomas Heidenreich, Elisabeth Hertenstein, Ulrich Voderholzer, Steffen Moritz

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Citations (Scopus)
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Abstract

Background: Obsessive-compulsive disorder (OCD) is a very disabling condition with a chronic course, if left untreated. Though cognitive behavioral treatment (CBT) with or without selective serotonin reuptake inhibitors (SSRI) is the method of choice, up to one third of individuals with obsessive-compulsive disorder (OCD) do not respond to treatment in terms of at least 35% improvement of symptoms. Mindfulness based cognitive therapy (MBCT) is an 8-week group program that could help OCD patients with no or only partial response to CBT to reduce OC symptoms and develop a helpful attitude towards obsessions and compulsive urges. Methods/design: This study is a prospective, bicentric, assessor-blinded, randomized, actively-controlled clinical trial. 128 patients with primary diagnosis of OCD according to DSM-IV and no or only partial response to CBT will be recruited from in- and outpatient services as well as online forums and the media. Patients will be randomized to either an MBCT intervention group or to a psycho-educative coaching group (OCD-EP) as an active control condition. All participants will undergo eight weekly sessions with a length of 120 minutes each of a structured group program. We hypothesize that MBCT will be superior to OCD-EP in reducing obsessive-compulsive symptoms as measured by the Yale-Brown-Obsessive-Compulsive Scale (Y-BOCS) following the intervention and at 6- and 12-months-follow-up. Secondary outcome measures include depressive symptoms, quality of life, metacognitive beliefs, self-compassion, mindful awareness and approach-avoidance tendencies as measured by an approach avoidance task. Discussion: The results of this study will elucidate the benefits of MBCT for OCD patients who did not sufficiently benefit from CBT. To our knowledge, this is the first randomized controlled study assessing the effects of MBCT on symptom severity and associated parameters in OCD.

Original languageEnglish
Article number314
Pages (from-to)1-9
Number of pages9
JournalBMC Psychiatry
Volume14
DOIs
Publication statusPublished - 18 Nov 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Mindfulness-based cognitive therapy
  • Obsessive-compulsive disorder
  • Randomized controlled trial

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    Külz, K. K., Landmann, S., Cludius, B., Hottenrott, B., Rose, N., Heidenreich, T., ... Moritz, S. (2014). Mindfulness-based cognitive therapy in obsessive-compulsive disorder: protocol of a randomized controlled trial. BMC Psychiatry, 14, 1-9. [314]. https://doi.org/10.1186/s12888-014-0314-8