Minimal effect of CNTF on the ultrastructure of axotomised motoneurones in the adult rat

T. Demetriou, R. M. Duberley, I. P. Johnson*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The ultrastructural effects of CNTF or BSA on the retrograde response of adult rat spinal motoneurones were quantified at 7 days. Axotomy with or without CNTF or BSA generally resulted in fragmentation of the rough endoplasmic reticulum (RER). One third of CNTF-treated motoneurones had RER with a more ordered lamella arrangement than controls. Decreased area of the Golgi apparatus was seen after CNTF and BSA treatment. Other features of the retrograde response were unaffected.

Original languageEnglish
Pages (from-to)312-317
Number of pages6
JournalBrain Research
Volume733
Issue number2
DOIs
Publication statusPublished - 16 Sep 1996
Externally publishedYes

Keywords

  • Adult
  • Axotomy
  • Ciliary neurotrophic factor
  • Motoneuron
  • Rat
  • Ultrastructure

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