The ultrastructural effects of CNTF or BSA on the retrograde response of adult rat spinal motoneurones were quantified at 7 days. Axotomy with or without CNTF or BSA generally resulted in fragmentation of the rough endoplasmic reticulum (RER). One third of CNTF-treated motoneurones had RER with a more ordered lamella arrangement than controls. Decreased area of the Golgi apparatus was seen after CNTF and BSA treatment. Other features of the retrograde response were unaffected.
- Ciliary neurotrophic factor