TY - JOUR
T1 - Minocycline-induced fulminant intracranial hypertension
AU - Fraser, Clare L.
AU - Biousse, Valerie
AU - Newman, Nancy J.
PY - 2012/8
Y1 - 2012/8
N2 - Objective: To describe the clinical course of an unusually severe case of minocycline-induced intracranial hypertension. Design : Case study. Setting: Academic medical center. Patient: Twelve-year-old girl with a fulminant course of intracranial hypertension. Interventions: Magnetic resonance imaging and venography of the brain, lumbar puncture, and optic nerve sheath fenestration. Results: Although the patient ceased minocycline treatment, there was ongoing and rapid worsening of symptoms and vision loss. Lumbar puncture, which normally acts as a temporizing measure to preserve vision, failed to prevent, and may even have precipitated, further deterioration in vision, necessitating surgical intervention with optic nerve sheath fenestration. Conclusion: Minocycline can cause a fulminantsyndrome of elevated intracranial pressure,with severe vision loss,even after the medication has been discontinued.
AB - Objective: To describe the clinical course of an unusually severe case of minocycline-induced intracranial hypertension. Design : Case study. Setting: Academic medical center. Patient: Twelve-year-old girl with a fulminant course of intracranial hypertension. Interventions: Magnetic resonance imaging and venography of the brain, lumbar puncture, and optic nerve sheath fenestration. Results: Although the patient ceased minocycline treatment, there was ongoing and rapid worsening of symptoms and vision loss. Lumbar puncture, which normally acts as a temporizing measure to preserve vision, failed to prevent, and may even have precipitated, further deterioration in vision, necessitating surgical intervention with optic nerve sheath fenestration. Conclusion: Minocycline can cause a fulminantsyndrome of elevated intracranial pressure,with severe vision loss,even after the medication has been discontinued.
UR - http://www.scopus.com/inward/record.url?scp=84865622742&partnerID=8YFLogxK
U2 - 10.1001/archneurol.2012.144
DO - 10.1001/archneurol.2012.144
M3 - Article
C2 - 22490325
AN - SCOPUS:84865622742
SN - 0003-9942
VL - 69
SP - 1067
EP - 1070
JO - Archives of Neurology
JF - Archives of Neurology
IS - 8
ER -