Mismatch negativity and cognitive and functional impairment in the schizophrenia prodrome. Preliminary results from the Minds in Transition (MinT) study

Rebbekah Atkinson, Vaughan Carr, Marc Seal, Helen Stain, Renate Thienel, Juanita Todd, Paul Tooney, Phillip Ward, Thomas Weickert, Paul Thompson, Ulrich Schall, Scott Clark, Jackie Curtis, Robyn Langdon, Carmel Loughland, Pat Michie, Maryanne O'Donnell, Georgie Paulik, Paul Rasser

    Research output: Contribution to journalMeeting abstract

    Abstract

    This project aims to gain a greater understanding of the changes in the brains of young people when they are developing a severe mental illness and to investigate the utility of an electrophysiological index of auditory sensory memory (mismatch negativity) as a predictor of transition to a schizophrenia spectrum disorder. Young people attending youth mental health centres in Newcastle, Orange and Sydney will be recruited over a 3.5-year period. Those meeting ultra-high risk (UHR) criteria as determined according to the Comprehensive Assessment of At Risk Mental States, will be followed up over a 12-month period. At baseline clinical, electrophysiological recordings, high-resolution structural and DTI magnetic resonance brain images, neurocognition and social cognition data are collected, with follow-up data collected after 12-months. This preliminary report describes correlations between baseline MMN amplitude data and symptoms and cognitive functioning. To date, baseline data have been obtained on 40 UHR participants. These preliminary results indicate associations between duration MMN and functional status, duration MMN and auditory verbal memory and frequency MMN and cognitive flexibility. Results suggest duration MMN may be tapping into underlying temporal lobe mechanisms, while frequency MMN may be tapping into underlying frontal lobe mechanisms and such deficits are occurring during the prodrome phase.
    Original languageEnglish
    Pages (from-to)218-219
    Number of pages2
    JournalClinical EEG and neuroscience
    Volume43
    Issue number3
    Publication statusPublished - 2012
    EventAustralasian Cognitive Neurosciences Conference (21st : 2011) - Sydney
    Duration: 9 Dec 201112 Dec 2011

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