Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii

Emma C. Barnes, Anthony R. Carroll, Rohan A. Davis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien- 15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites.

Original languageEnglish
Pages (from-to)1888-1893
Number of pages6
JournalJournal of Natural Products
Volume74
Issue number9
DOIs
Publication statusPublished - 23 Sep 2011
Externally publishedYes

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