Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii

Emma C. Barnes; Anthony R. Carroll; Rohan A. Davis

doi:10.1021/np2003676

Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii

Emma C. Barnes, Anthony R. Carroll, Rohan A. Davis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien- 15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites.

Original language	English
Pages (from-to)	1888-1893
Number of pages	6
Journal	Journal of Natural Products
Volume	74
Issue number	9
DOIs	https://doi.org/10.1021/np2003676
Publication status	Published - 23 Sept 2011
Externally published	Yes

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title = "Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii",

abstract = "Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien- 15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites.",

author = "Barnes, {Emma C.} and Carroll, {Anthony R.} and Davis, {Rohan A.}",

year = "2011",

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AU - Carroll, Anthony R.

AU - Davis, Rohan A.

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Y1 - 2011/9/23

N2 - Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien- 15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites.

AB - Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien- 15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii

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