Mitochondrial disease: A pulmonary and critical-care medicine perspective

Alison S. Clay, Behnia Mehrdad, Kevin K. Brown

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


The clinical spectrum of mitochondrial diseases has expanded dramatically in the last decade. Abnormalities of mitochondrial function are now thought to participate in a number of common adult diseases, ranging from exercise intolerance to aging. This review outlines the common presentations of mitochondrial disease in ICUs and in the outpatient setting and discusses current diagnostic and therapeutic options as they pertain to the pulmonary and critical-care physician.

Original languageEnglish
Pages (from-to)634-648
Number of pages15
Issue number2
Publication statusPublished - 2001
Externally publishedYes


  • Critical care
  • Exercise intolerance
  • Exercise testing
  • Hypoventilation
  • Lactic acidosis
  • Mitochondria
  • Mitochondrial genome
  • Mitochondrial myopathy
  • Muscle biopsy
  • Muscle weakness


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