Abstract
The clinical spectrum of mitochondrial diseases has expanded dramatically in the last decade. Abnormalities of mitochondrial function are now thought to participate in a number of common adult diseases, ranging from exercise intolerance to aging. This review outlines the common presentations of mitochondrial disease in ICUs and in the outpatient setting and discusses current diagnostic and therapeutic options as they pertain to the pulmonary and critical-care physician.
| Original language | English |
|---|---|
| Pages (from-to) | 634-648 |
| Number of pages | 15 |
| Journal | Chest |
| Volume | 120 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
Keywords
- Critical care
- Exercise intolerance
- Exercise testing
- Hypoventilation
- Lactic acidosis
- Mitochondria
- Mitochondrial genome
- Mitochondrial myopathy
- Muscle biopsy
- Muscle weakness