Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

Angela Pyle; Thomas Foltynie; Watcharee Tiangyou; Claire Lambert; Sharon M. Keers; Liesl M. Allcock; Jill Davison; Simon J. Lewis; Robert H. Perry; Roger Barker; David J. Burn; Patrick F. Chinnery

doi:10.1002/ana.20417

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

Angela Pyle, Thomas Foltynie, Watcharee Tiangyou, Claire Lambert, Sharon M. Keers, Liesl M. Allcock, Jill Davison, Simon J. Lewis, Robert H. Perry, Roger Barker, David J. Burn, Patrick F. Chinnery^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

169 Citations (Scopus)

Abstract

There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or die UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.

Original language	English
Pages (from-to)	564-567
Number of pages	4
Journal	Annals of Neurology
Volume	57
Issue number	4
DOIs	https://doi.org/10.1002/ana.20417
Publication status	Published - Apr 2005
Externally published	Yes

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10.1002/ana.20417

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title = "Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD",

abstract = "There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or die UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.",

author = "Angela Pyle and Thomas Foltynie and Watcharee Tiangyou and Claire Lambert and Keers, {Sharon M.} and Allcock, {Liesl M.} and Jill Davison and Lewis, {Simon J.} and Perry, {Robert H.} and Roger Barker and Burn, {David J.} and Chinnery, {Patrick F.}",

year = "2005",

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T1 - Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

AU - Pyle, Angela

AU - Foltynie, Thomas

AU - Tiangyou, Watcharee

AU - Lambert, Claire

AU - Keers, Sharon M.

AU - Allcock, Liesl M.

AU - Davison, Jill

AU - Lewis, Simon J.

AU - Perry, Robert H.

AU - Barker, Roger

AU - Burn, David J.

AU - Chinnery, Patrick F.

PY - 2005/4

Y1 - 2005/4

N2 - There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or die UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.

AB - There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or die UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.

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SN - 0364-5134

VL - 57

SP - 564

EP - 567

JO - Annals of Neurology

JF - Annals of Neurology

IS - 4

ER -

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

Abstract

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