Mitochondrial DNA haplogroups J and K are note protective for Parkinson's disease in the Australian community

Prachi Mehta, George D. Mellick, Dominic B. Rowe, Glenda M. Halliday, Michael M. Jones, Neil Manwaring, Himesha Vandebona, Peter A. Silburn, Jie Jin Wang, Paul Mitchell, Carolyn M. Sue

Research output: Contribution to journalArticleResearchpeer-review

Abstract

MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/ RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6-12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5-8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2-11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.

LanguageEnglish
Pages290-292
Number of pages3
JournalMovement Disorders
Volume24
Issue number2
DOIs
Publication statusPublished - 30 Jan 2009
Externally publishedYes

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Mitochondrial DNA
Parkinson Disease
Population Control
Restriction Fragment Length Polymorphisms
Polymerase Chain Reaction

Keywords

  • Mitochondrial DNA haplogroups
  • Parkinson's disease
  • Prevalence

Cite this

Mehta, Prachi ; Mellick, George D. ; Rowe, Dominic B. ; Halliday, Glenda M. ; Jones, Michael M. ; Manwaring, Neil ; Vandebona, Himesha ; Silburn, Peter A. ; Wang, Jie Jin ; Mitchell, Paul ; Sue, Carolyn M. / Mitochondrial DNA haplogroups J and K are note protective for Parkinson's disease in the Australian community. In: Movement Disorders. 2009 ; Vol. 24, No. 2. pp. 290-292.
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abstract = "MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/ RFLP techniques. Of the 890 subjects with PD, 10.6{\%} were haplogroup J (95{\%} CI 8.6-12.8, n = 94) and 7.1{\%} were haplogroup K (95{\%} CI 5.5-8.9, n = 63). In our controls, 10.2{\%} belonged to haplogroup J (95{\%} CI 9.2-11.2, n = 356), and 7.8{\%} were in haplogroup K (95{\%} CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.",
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Mehta, P, Mellick, GD, Rowe, DB, Halliday, GM, Jones, MM, Manwaring, N, Vandebona, H, Silburn, PA, Wang, JJ, Mitchell, P & Sue, CM 2009, 'Mitochondrial DNA haplogroups J and K are note protective for Parkinson's disease in the Australian community', Movement Disorders, vol. 24, no. 2, pp. 290-292. https://doi.org/10.1002/mds.22389

Mitochondrial DNA haplogroups J and K are note protective for Parkinson's disease in the Australian community. / Mehta, Prachi; Mellick, George D.; Rowe, Dominic B.; Halliday, Glenda M.; Jones, Michael M.; Manwaring, Neil; Vandebona, Himesha; Silburn, Peter A.; Wang, Jie Jin; Mitchell, Paul; Sue, Carolyn M.

In: Movement Disorders, Vol. 24, No. 2, 30.01.2009, p. 290-292.

Research output: Contribution to journalArticleResearchpeer-review

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