Mitochondrial dysfunction in Alzheimer’s disease: a proteomics perspective

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22 Citations (Scopus)


Mitochondrial dysfunction is involved in Alzheimer’s disease (AD) pathogenesis. Mitochondria have their own genetic material; however, most of their proteins (∼99%) are synthesized as precursors on cytosolic ribosomes, and then imported into the mitochondria. Therefore, exploring proteome changes in these organelles can yield valuable information and shed light on the molecular mechanisms underlying mitochondrial dysfunction in AD. Here we review AD associated mitochondrial changes including the effects of amyloid beta and tau protein accumulation on the mitochondrial proteome. We also discuss the relationship of ApoE genetic polymorphism with mitochondrial changes, and present a meta-analysis of various differentially expressed proteins in the mitochondria in AD.
Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalExpert Review of Proteomics
Issue number4
Early online date3 May 2021
Publication statusPublished - 2021


  • Alzheimer’s disease
  • Mitochondrial dysfunction
  • Proteomics


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