Mitochondrial polymorphic variation in patients with early-onset Alzheimer's disease

Alireza Meratian, Parisa Azadfar, Leila Akbari, Samira Sheibani-Nia, Massoud Houshmand

Research output: Contribution to journalMeeting abstractpeer-review


Objectives. Mitochondria, increasingly implicated as sensors and executioners in the cell's decision to live or die, are involved in the pathogenesis of most neurodegenerative diseases including Alzheimer's disease (AD), considered the most common age-related neurodegenerative disorder. The clinical symptoms of AD include a progressive loss of memory and impairment of cognitive ability. Mitochondrial DNA mutations are inherited maternally in a non-Mendelian manner.

Methods. In this study we analyzed the variation of NDII, COII and COIII mitochondrial genes in 24 patients with Early-Onset AD (EOAD) and 100 individuals as the control group. After PCR amplification, genotypes were analyzed with sequencing methods.

Results. Four variations were polymorphic mutations: A4529T in NDII gene, A7424G and G8251A in COII gene, and G9966A in COIII gene in 4 Iranian patints with EOAD. Each of these variations was found in one patient.

Conclusions. We believe these polymorphisms are unrelated to EOAD in Iranian patients.
Original languageEnglish
Pages (from-to)723-724
Number of pages2
JournalNeurobiology of Aging
Issue number3
Publication statusPublished - Mar 2014
Externally publishedYes
EventSixth International Conference on Alzheimer’s Disease and Related Disorders in the Middle East - Istanbul, Turkey
Duration: 25 Oct 201327 Oct 2013


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